Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers

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Epidermal growth factor receptor (EGFR) is overexpressed in various cancers, including non-small cell lung cancer (NSCLC), and in some somatic cells at a limited level, rendering it an attractive antitumor target. In this study, we engineered chimeric antigen receptor (CAR)-T cells using the piggyBa...

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Detalles Bibliográficos
Autores principales: Chinsuwan, Thanyavi, Hirabayashi, Koichi, Mishima, Shuji, Hasegawa, Aiko, Tanaka, Miyuki, Mochizuki, Hidemi, Shimoi, Akihito, Murakami, Takashi, Yagyu, Shigeki, Shimizu, Kimihiro, Nakazawa, Yozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562194/
https://www.ncbi.nlm.nih.gov/pubmed/37822488
http://dx.doi.org/10.1016/j.omto.2023.100728
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