Multitissue H3K27ac profiling of GTEx samples links epigenomic variation to disease

Genetic variants associated with complex traits are primarily noncoding, and their effects on gene-regulatory activity remain largely uncharacterized. To address this, we profile epigenomic variation of histone mark H3K27ac across 387 brain, heart, muscle and lung samples from Genotype-Tissue Expres...

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Detalles Bibliográficos
Autores principales: Hou, Lei, Xiong, Xushen, Park, Yongjin, Boix, Carles, James, Benjamin, Sun, Na, He, Liang, Patel, Aman, Zhang, Zhizhuo, Molinie, Benoit, Van Wittenberghe, Nicholas, Steelman, Scott, Nusbaum, Chad, Aguet, François, Ardlie, Kristin G., Kellis, Manolis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562256/
https://www.ncbi.nlm.nih.gov/pubmed/37770633
http://dx.doi.org/10.1038/s41588-023-01509-5

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