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Harnessing the power of synthetic data in healthcare: innovation, application, and privacy

Data-driven decision-making in modern healthcare underpins innovation and predictive analytics in public health and clinical research. Synthetic data has shown promise in finance and economics to improve risk assessment, portfolio optimization, and algorithmic trading. However, higher stakes, potent...

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Detalles Bibliográficos
Autores principales: Giuffrè, Mauro, Shung, Dennis L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562365/
https://www.ncbi.nlm.nih.gov/pubmed/37813960
http://dx.doi.org/10.1038/s41746-023-00927-3
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author Giuffrè, Mauro
Shung, Dennis L.
author_facet Giuffrè, Mauro
Shung, Dennis L.
author_sort Giuffrè, Mauro
collection PubMed
description Data-driven decision-making in modern healthcare underpins innovation and predictive analytics in public health and clinical research. Synthetic data has shown promise in finance and economics to improve risk assessment, portfolio optimization, and algorithmic trading. However, higher stakes, potential liabilities, and healthcare practitioner distrust make clinical use of synthetic data difficult. This paper explores the potential benefits and limitations of synthetic data in the healthcare analytics context. We begin with real-world healthcare applications of synthetic data that informs government policy, enhance data privacy, and augment datasets for predictive analytics. We then preview future applications of synthetic data in the emergent field of digital twin technology. We explore the issues of data quality and data bias in synthetic data, which can limit applicability across different applications in the clinical context, and privacy concerns stemming from data misuse and risk of re-identification. Finally, we evaluate the role of regulatory agencies in promoting transparency and accountability and propose strategies for risk mitigation such as Differential Privacy (DP) and a dataset chain of custody to maintain data integrity, traceability, and accountability. Synthetic data can improve healthcare, but measures to protect patient well-being and maintain ethical standards are key to promote responsible use.
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spelling pubmed-105623652023-10-11 Harnessing the power of synthetic data in healthcare: innovation, application, and privacy Giuffrè, Mauro Shung, Dennis L. NPJ Digit Med Perspective Data-driven decision-making in modern healthcare underpins innovation and predictive analytics in public health and clinical research. Synthetic data has shown promise in finance and economics to improve risk assessment, portfolio optimization, and algorithmic trading. However, higher stakes, potential liabilities, and healthcare practitioner distrust make clinical use of synthetic data difficult. This paper explores the potential benefits and limitations of synthetic data in the healthcare analytics context. We begin with real-world healthcare applications of synthetic data that informs government policy, enhance data privacy, and augment datasets for predictive analytics. We then preview future applications of synthetic data in the emergent field of digital twin technology. We explore the issues of data quality and data bias in synthetic data, which can limit applicability across different applications in the clinical context, and privacy concerns stemming from data misuse and risk of re-identification. Finally, we evaluate the role of regulatory agencies in promoting transparency and accountability and propose strategies for risk mitigation such as Differential Privacy (DP) and a dataset chain of custody to maintain data integrity, traceability, and accountability. Synthetic data can improve healthcare, but measures to protect patient well-being and maintain ethical standards are key to promote responsible use. Nature Publishing Group UK 2023-10-09 /pmc/articles/PMC10562365/ /pubmed/37813960 http://dx.doi.org/10.1038/s41746-023-00927-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Perspective
Giuffrè, Mauro
Shung, Dennis L.
Harnessing the power of synthetic data in healthcare: innovation, application, and privacy
title Harnessing the power of synthetic data in healthcare: innovation, application, and privacy
title_full Harnessing the power of synthetic data in healthcare: innovation, application, and privacy
title_fullStr Harnessing the power of synthetic data in healthcare: innovation, application, and privacy
title_full_unstemmed Harnessing the power of synthetic data in healthcare: innovation, application, and privacy
title_short Harnessing the power of synthetic data in healthcare: innovation, application, and privacy
title_sort harnessing the power of synthetic data in healthcare: innovation, application, and privacy
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562365/
https://www.ncbi.nlm.nih.gov/pubmed/37813960
http://dx.doi.org/10.1038/s41746-023-00927-3
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