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A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models

In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated forms of islet amyloid polypeptide (IAPP) consisting of sol...

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Detalles Bibliográficos
Autores principales:	Wirth, Fabian, Heitz, Fabrice D., Seeger, Christine, Combaluzier, Ioana, Breu, Karin, Denroche, Heather C., Thevenet, Julien, Osto, Melania, Arosio, Paolo, Kerr-Conte, Julie, Verchere, C. Bruce, Pattou, François, Lutz, Thomas A., Donath, Marc Y., Hock, Christoph, Nitsch, Roger M., Grimm, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562398/ https://www.ncbi.nlm.nih.gov/pubmed/37813862 http://dx.doi.org/10.1038/s41467-023-41986-0

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