GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics

G protein-coupled receptors are important drug targets that engage and activate signaling transducers in multiple cellular compartments. Delineating therapeutic signaling from signaling associated with adverse events is an important step towards rational drug design. The glucagon-like peptide-1 rece...

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Detalles Bibliográficos
Autores principales: Wright, Shane C., Motso, Aikaterini, Koutsilieri, Stefania, Beusch, Christian M., Sabatier, Pierre, Berghella, Alessandro, Blondel-Tepaz, Élodie, Mangenot, Kimberley, Pittarokoilis, Ioannis, Sismanoglou, Despoina-Christina, Le Gouill, Christian, Olsen, Jesper V., Zubarev, Roman A., Lambert, Nevin A., Hauser, Alexander S., Bouvier, Michel, Lauschke, Volker M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562414/
https://www.ncbi.nlm.nih.gov/pubmed/37813859
http://dx.doi.org/10.1038/s41467-023-41893-4

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