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Alveolar macrophages in lung cancer: opportunities and challenges
Alveolar macrophages (AMs) are critical components of the innate defense mechanism in the lung. Nestled tightly within the alveoli, AMs, derived from the yolk-sac or bone marrow, can phagocytose foreign particles, defend the host against pathogens, recycle surfactant, and promptly respond to inhaled...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562548/ https://www.ncbi.nlm.nih.gov/pubmed/37822933 http://dx.doi.org/10.3389/fimmu.2023.1268939 |
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author | Chang, Cheng-Yen Armstrong, Dominique Corry, David B. Kheradmand, Farrah |
author_facet | Chang, Cheng-Yen Armstrong, Dominique Corry, David B. Kheradmand, Farrah |
author_sort | Chang, Cheng-Yen |
collection | PubMed |
description | Alveolar macrophages (AMs) are critical components of the innate defense mechanism in the lung. Nestled tightly within the alveoli, AMs, derived from the yolk-sac or bone marrow, can phagocytose foreign particles, defend the host against pathogens, recycle surfactant, and promptly respond to inhaled noxious stimuli. The behavior of AMs is tightly dependent on the environmental cues whereby infection, chronic inflammation, and associated metabolic changes can repolarize their effector functions in the lungs. Several factors within the tumor microenvironment can re-educate AMs, resulting in tumor growth, and reducing immune checkpoint inhibitors (ICIs) efficacy in patients treated for non-small cell lung cancer (NSCLC). The plasticity of AMs and their critical function in altering tumor responses to ICIs make them a desirable target in lung cancer treatment. New strategies have been developed to target AMs in solid tumors reprograming their suppressive function and boosting the efficacy of ICIs. Here, we review the phenotypic and functional changes in AMs in response to sterile inflammation and in NSCLC that could be critical in tumor growth and metastasis. Opportunities in altering AMs’ function include harnessing their potential function in trained immunity, a concept borrowed from memory response to infections, which could be explored therapeutically in managing lung cancer treatment. |
format | Online Article Text |
id | pubmed-10562548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105625482023-10-11 Alveolar macrophages in lung cancer: opportunities and challenges Chang, Cheng-Yen Armstrong, Dominique Corry, David B. Kheradmand, Farrah Front Immunol Immunology Alveolar macrophages (AMs) are critical components of the innate defense mechanism in the lung. Nestled tightly within the alveoli, AMs, derived from the yolk-sac or bone marrow, can phagocytose foreign particles, defend the host against pathogens, recycle surfactant, and promptly respond to inhaled noxious stimuli. The behavior of AMs is tightly dependent on the environmental cues whereby infection, chronic inflammation, and associated metabolic changes can repolarize their effector functions in the lungs. Several factors within the tumor microenvironment can re-educate AMs, resulting in tumor growth, and reducing immune checkpoint inhibitors (ICIs) efficacy in patients treated for non-small cell lung cancer (NSCLC). The plasticity of AMs and their critical function in altering tumor responses to ICIs make them a desirable target in lung cancer treatment. New strategies have been developed to target AMs in solid tumors reprograming their suppressive function and boosting the efficacy of ICIs. Here, we review the phenotypic and functional changes in AMs in response to sterile inflammation and in NSCLC that could be critical in tumor growth and metastasis. Opportunities in altering AMs’ function include harnessing their potential function in trained immunity, a concept borrowed from memory response to infections, which could be explored therapeutically in managing lung cancer treatment. Frontiers Media S.A. 2023-09-26 /pmc/articles/PMC10562548/ /pubmed/37822933 http://dx.doi.org/10.3389/fimmu.2023.1268939 Text en Copyright © 2023 Chang, Armstrong, Corry and Kheradmand https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Chang, Cheng-Yen Armstrong, Dominique Corry, David B. Kheradmand, Farrah Alveolar macrophages in lung cancer: opportunities and challenges |
title | Alveolar macrophages in lung cancer: opportunities and challenges |
title_full | Alveolar macrophages in lung cancer: opportunities and challenges |
title_fullStr | Alveolar macrophages in lung cancer: opportunities and challenges |
title_full_unstemmed | Alveolar macrophages in lung cancer: opportunities and challenges |
title_short | Alveolar macrophages in lung cancer: opportunities and challenges |
title_sort | alveolar macrophages in lung cancer: opportunities and challenges |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562548/ https://www.ncbi.nlm.nih.gov/pubmed/37822933 http://dx.doi.org/10.3389/fimmu.2023.1268939 |
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