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The role of SGLT2i in attenuating residual cardiovascular risk through blood pressure-lowering: mechanistic insights and perspectives

Sodium glucose cotransporter 2 inhibitors (SGLT2) have been increasingly pursued as a promising target for addressing residual cardiovascular risk. Prior trials demonstrated that SGLT2i not only promotes glucose-lowering, but also improves endothelial dysfunction, adiposity, fluid overload, and insu...

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Autores principales: Barreto, Joaquim, Campos-Staffico, Alessandra M., Nadruz, Wilson, Quinaglia, Thiago, Sposito, Andrei C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562622/
https://www.ncbi.nlm.nih.gov/pubmed/37822556
http://dx.doi.org/10.3389/fcdhc.2023.1243530
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author Barreto, Joaquim
Campos-Staffico, Alessandra M.
Nadruz, Wilson
Quinaglia, Thiago
Sposito, Andrei C.
author_facet Barreto, Joaquim
Campos-Staffico, Alessandra M.
Nadruz, Wilson
Quinaglia, Thiago
Sposito, Andrei C.
author_sort Barreto, Joaquim
collection PubMed
description Sodium glucose cotransporter 2 inhibitors (SGLT2) have been increasingly pursued as a promising target for addressing residual cardiovascular risk. Prior trials demonstrated that SGLT2i not only promotes glucose-lowering, but also improves endothelial dysfunction, adiposity, fluid overload, and insulin sensitivity thus contributing to hemodynamic changes implicated in its cardiorenal benefits. The mechanisms in the effect of SGLT2i on blood pressure and their potential role in preventing cardiovascular events are hereby revised.
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spelling pubmed-105626222023-10-11 The role of SGLT2i in attenuating residual cardiovascular risk through blood pressure-lowering: mechanistic insights and perspectives Barreto, Joaquim Campos-Staffico, Alessandra M. Nadruz, Wilson Quinaglia, Thiago Sposito, Andrei C. Front Clin Diabetes Healthc Clinical Diabetes and Healthcare Sodium glucose cotransporter 2 inhibitors (SGLT2) have been increasingly pursued as a promising target for addressing residual cardiovascular risk. Prior trials demonstrated that SGLT2i not only promotes glucose-lowering, but also improves endothelial dysfunction, adiposity, fluid overload, and insulin sensitivity thus contributing to hemodynamic changes implicated in its cardiorenal benefits. The mechanisms in the effect of SGLT2i on blood pressure and their potential role in preventing cardiovascular events are hereby revised. Frontiers Media S.A. 2023-09-26 /pmc/articles/PMC10562622/ /pubmed/37822556 http://dx.doi.org/10.3389/fcdhc.2023.1243530 Text en Copyright © 2023 Barreto, Campos-Staffico, Nadruz, Quinaglia and Sposito https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Clinical Diabetes and Healthcare
Barreto, Joaquim
Campos-Staffico, Alessandra M.
Nadruz, Wilson
Quinaglia, Thiago
Sposito, Andrei C.
The role of SGLT2i in attenuating residual cardiovascular risk through blood pressure-lowering: mechanistic insights and perspectives
title The role of SGLT2i in attenuating residual cardiovascular risk through blood pressure-lowering: mechanistic insights and perspectives
title_full The role of SGLT2i in attenuating residual cardiovascular risk through blood pressure-lowering: mechanistic insights and perspectives
title_fullStr The role of SGLT2i in attenuating residual cardiovascular risk through blood pressure-lowering: mechanistic insights and perspectives
title_full_unstemmed The role of SGLT2i in attenuating residual cardiovascular risk through blood pressure-lowering: mechanistic insights and perspectives
title_short The role of SGLT2i in attenuating residual cardiovascular risk through blood pressure-lowering: mechanistic insights and perspectives
title_sort role of sglt2i in attenuating residual cardiovascular risk through blood pressure-lowering: mechanistic insights and perspectives
topic Clinical Diabetes and Healthcare
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562622/
https://www.ncbi.nlm.nih.gov/pubmed/37822556
http://dx.doi.org/10.3389/fcdhc.2023.1243530
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