The impact of upper motor neuron involvement on clinical features, disease progression and prognosis in amyotrophic lateral sclerosis

OBJECTIVES: In amyotrophic lateral sclerosis (ALS) both upper (UMNs) and lower motor neurons (LMNs) are involved in the process of neurodegeneration, accounting for the great disease heterogeneity. We evaluated the associations of the burden of UMN impairment, assessed through the Penn Upper Motor N...

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Detalles Bibliográficos
Autores principales: Colombo, Eleonora, Gentile, Francesco, Maranzano, Alessio, Doretti, Alberto, Verde, Federico, Olivero, Marco, Gagliardi, Delia, Faré, Matteo, Meneri, Megi, Poletti, Barbara, Maderna, Luca, Corti, Stefania, Corbo, Massimo, Morelli, Claudia, Silani, Vincenzo, Ticozzi, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562695/
https://www.ncbi.nlm.nih.gov/pubmed/37822527
http://dx.doi.org/10.3389/fneur.2023.1249429

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