Cargando…

The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome

Both the number and regenerative activity of hair follicle stem cells (HFSCs) are regulated by Vav2, a GDP/GTP exchange factor involved in the catalytic stimulation of the GTPases Rac1 and RhoA. However, whether Vav2 signaling changes in HFSCs over the mouse lifespan is not yet known. Using a mouse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lorenzo-Martín, L. Francisco, Bustelo, Xosé R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562702/ https://www.ncbi.nlm.nih.gov/pubmed/37822868 http://dx.doi.org/10.3389/fcell.2023.1252834

Ejemplares similares

The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
por: Lorenzo-Martín, L. Francisco, et al.
Publicado: (2022)

The Rho GTPase Cell Division Cycle 42 Regulates Stereocilia Development in Cochlear Hair Cells
por: Du, Haibo, et al.
Publicado: (2021)

Vav family exchange factors: an integrated regulatory and functional view
por: Bustelo, Xosé R
Publicado: (2014)

Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer
por: Lorenzo-Martín, Luis Francisco, et al.
Publicado: (2020)

Multifaceted Rho GTPase Signaling at the Endomembranes
por: Phuyal, Santosh, et al.
Publicado: (2019)

The Rho Exchange Factors Vav2 and Vav3 Favor Skin Tumor Initiation and Promotion by Engaging Extracellular Signaling Loops
por: Menacho-Márquez, Mauricio, et al.
Publicado: (2013)

Targeting Rho GTPase Signaling Networks in Cancer
por: Clayton, Natasha S., et al.
Publicado: (2020)

β-Catenin Signaling Evokes Hair Follicle Senescence by Accelerating the Differentiation of Hair Follicle Mesenchymal Progenitors
por: Han, Jimin, et al.
Publicado: (2022)

Vav2 Pharmaco-Mimetic Mice Reveal the Therapeutic Value and Caveats of the Catalytic Inactivation of a Rho Exchange Factor
por: Lorenzo-Martín, L. Francisco, et al.
Publicado: (2020)

TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
por: Lavanderos, Boris, et al.
Publicado: (2020)

Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature
por: Wang, Shanhe, et al.
Publicado: (2021)

IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation
por: Gong, Lin, et al.
Publicado: (2020)

Rho GTPases in Skeletal Muscle Development and Homeostasis
por: Rodríguez-Fdez, Sonia, et al.
Publicado: (2021)

The guanine nucleotide exchange factor Vav3 intervenes in the migration pathway of oligodendrocyte precursor cells on tenascin-C
por: Schäfer, Ina, et al.
Publicado: (2022)

Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632
por: Wen, Lihong, et al.
Publicado: (2021)

Editorial: Hair Follicle Stem Cell Regeneration in Aging
por: Lei, Mingxing, et al.
Publicado: (2021)

Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles
por: Lin, Xiangyu, et al.
Publicado: (2022)

Hair Follicle Morphogenesis During Embryogenesis, Neogenesis, and Organogenesis
por: Park, Sangbum
Publicado: (2022)

Rho and Rab Family Small GTPases in the Regulation of Membrane Polarity in Epithelial Cells
por: Ebnet, Klaus, et al.
Publicado: (2022)

iPSC-based approach for human hair follicle regeneration
por: Vatanashevanopakorn, Chinnavuth, et al.
Publicado: (2023)

Regulation of Rho GTPases in the Vasculature by Cullin3-Based E3 Ligase Complexes
por: Podieh, Fabienne, et al.
Publicado: (2021)

Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth
por: Zhang, Jiarui, et al.
Publicado: (2021)

The Vav GEF Family: An Evolutionary and Functional Perspective
por: Rodríguez-Fdez, Sonia, et al.
Publicado: (2019)

Atlas of Prenatal Hair Follicle Morphogenesis Using the Pig as a Model System
por: Jiang, Yao, et al.
Publicado: (2021)

Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth
por: Zhang, Yufan, et al.
Publicado: (2021)

Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis
por: de Groot, Simon C., et al.
Publicado: (2021)

An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities
por: Daszczuk, Patrycja, et al.
Publicado: (2020)

Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging
por: Chen, Jian, et al.
Publicado: (2021)

The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives
por: Yang, Min, et al.
Publicado: (2021)

CD40L Reverse Signaling Influences Dendrite Spine Morphology and Expression of PSD-95 and Rho Small GTPases
por: Carriba, Paulina, et al.
Publicado: (2020)

Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes
por: Rodríguez-Fdez, Sonia, et al.
Publicado: (2020)

Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development
por: Vishlaghi, Neda, et al.
Publicado: (2020)

Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation
por: Morgun, Elena I., et al.
Publicado: (2020)

Differential Requirement of Vav Proteins for Btk-dependent and –Independent Signaling During B Cell Development
por: Betzler, Annika C., et al.
Publicado: (2022)

An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis
por: Laurin, Melanie, et al.
Publicado: (2019)

Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway
por: Zhang, Weidong, et al.
Publicado: (2021)

Connecting Metabolic Rewiring With Phenotype Switching in Melanoma
por: Falletta, Paola, et al.
Publicado: (2022)

Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for in vitro hair follicle cloning
por: Lim, Sheng Jye, et al.
Publicado: (2016)

Intravenous Transplantation of Human Hair Follicle-Derived Mesenchymal Stem Cells Ameliorates Trabecular Bone Loss in Osteoporotic Mice
por: Lin, Longshuai, et al.
Publicado: (2022)

Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity
por: González, Nazareno, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_eprc8ef44cqagotdapj4157rs7