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Molecular sensitization patterns to cat and dog allergens in Lithuanian children population
BACKGROUND: Over the last few decades, there was observed an increase of asthma and allergic rhinitis cases caused by allergy to pets. OBJECTIVE: This study aimed to analyze molecular sensitization patterns to dog and cat allergens in Lithuanian children who were experiencing allergy-like symptoms....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
World Allergy Organization
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562746/ https://www.ncbi.nlm.nih.gov/pubmed/37822703 http://dx.doi.org/10.1016/j.waojou.2023.100827 |
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author | Eidukaite, Audrone Gorbikova, Evelina Miskinyte, Monika Adomaite, Ieva Rudzeviciene, Odilija Siaurys, Almantas Miskiniene, Asta |
author_facet | Eidukaite, Audrone Gorbikova, Evelina Miskinyte, Monika Adomaite, Ieva Rudzeviciene, Odilija Siaurys, Almantas Miskiniene, Asta |
author_sort | Eidukaite, Audrone |
collection | PubMed |
description | BACKGROUND: Over the last few decades, there was observed an increase of asthma and allergic rhinitis cases caused by allergy to pets. OBJECTIVE: This study aimed to analyze molecular sensitization patterns to dog and cat allergens in Lithuanian children who were experiencing allergy-like symptoms. MATERIALS AND METHODS: A total of 574 children (0–18 years) were tested for allergen-specific immunoglobulin E (sIgE) levels with ALEX(2) (ALEX(2®), Allergy Explorer Test System). Positive sera were further analyzed for sensitization to cat (Fel d 1, Fel d 2, Fel d 4, and Fel d 7) and dog (Can f 1, Can f 2, Can f 3, Can f 4, Can f 5, and Can f 6) allergen components. RESULTS: Two hundred forty-seven children tested positive (sIgE ≥0.3 kUA/L) to at least 1 dog or cat allergen component. There were 61.1% children sensitized to components from both sources, 29.2% – exclusively to cat, and 9.7% – to dog components. The major sensitizers were Fel d 1 (84.8%) and Can f 1 (59.4%). There were 42.9% patients sensitized to 3 or more different mammalian protein families and 40.4% – to 3 or more lipocalins. There were 5.7% of children sensitized both to Fel d 1 + Fel d 4 and Can f 1/2 + Can f 5, indicating the high risk of severe asthma. Monosensitization to Fel d 1 was the dominant pattern among Lithuanian children (26.3%). CONCLUSION: The majority of children were cat/dog-polysensitized, although sensitization only to cat allergens was most observed. Extensive molecular profiling can be an useful tool for accurate true sensitization diagnosis and prognosis of disease severity. |
format | Online Article Text |
id | pubmed-10562746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | World Allergy Organization |
record_format | MEDLINE/PubMed |
spelling | pubmed-105627462023-10-11 Molecular sensitization patterns to cat and dog allergens in Lithuanian children population Eidukaite, Audrone Gorbikova, Evelina Miskinyte, Monika Adomaite, Ieva Rudzeviciene, Odilija Siaurys, Almantas Miskiniene, Asta World Allergy Organ J Full Length Article BACKGROUND: Over the last few decades, there was observed an increase of asthma and allergic rhinitis cases caused by allergy to pets. OBJECTIVE: This study aimed to analyze molecular sensitization patterns to dog and cat allergens in Lithuanian children who were experiencing allergy-like symptoms. MATERIALS AND METHODS: A total of 574 children (0–18 years) were tested for allergen-specific immunoglobulin E (sIgE) levels with ALEX(2) (ALEX(2®), Allergy Explorer Test System). Positive sera were further analyzed for sensitization to cat (Fel d 1, Fel d 2, Fel d 4, and Fel d 7) and dog (Can f 1, Can f 2, Can f 3, Can f 4, Can f 5, and Can f 6) allergen components. RESULTS: Two hundred forty-seven children tested positive (sIgE ≥0.3 kUA/L) to at least 1 dog or cat allergen component. There were 61.1% children sensitized to components from both sources, 29.2% – exclusively to cat, and 9.7% – to dog components. The major sensitizers were Fel d 1 (84.8%) and Can f 1 (59.4%). There were 42.9% patients sensitized to 3 or more different mammalian protein families and 40.4% – to 3 or more lipocalins. There were 5.7% of children sensitized both to Fel d 1 + Fel d 4 and Can f 1/2 + Can f 5, indicating the high risk of severe asthma. Monosensitization to Fel d 1 was the dominant pattern among Lithuanian children (26.3%). CONCLUSION: The majority of children were cat/dog-polysensitized, although sensitization only to cat allergens was most observed. Extensive molecular profiling can be an useful tool for accurate true sensitization diagnosis and prognosis of disease severity. World Allergy Organization 2023-10-04 /pmc/articles/PMC10562746/ /pubmed/37822703 http://dx.doi.org/10.1016/j.waojou.2023.100827 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Full Length Article Eidukaite, Audrone Gorbikova, Evelina Miskinyte, Monika Adomaite, Ieva Rudzeviciene, Odilija Siaurys, Almantas Miskiniene, Asta Molecular sensitization patterns to cat and dog allergens in Lithuanian children population |
title | Molecular sensitization patterns to cat and dog allergens in Lithuanian children population |
title_full | Molecular sensitization patterns to cat and dog allergens in Lithuanian children population |
title_fullStr | Molecular sensitization patterns to cat and dog allergens in Lithuanian children population |
title_full_unstemmed | Molecular sensitization patterns to cat and dog allergens in Lithuanian children population |
title_short | Molecular sensitization patterns to cat and dog allergens in Lithuanian children population |
title_sort | molecular sensitization patterns to cat and dog allergens in lithuanian children population |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562746/ https://www.ncbi.nlm.nih.gov/pubmed/37822703 http://dx.doi.org/10.1016/j.waojou.2023.100827 |
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