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Naive T lymphocytes chemotax long distance to CCL21 but not to a source of bioactive S1P

Naive T lymphocytes traffic through the organism in search for antigen, alternating between blood and secondary lymphoid organs. Lymphocyte homing to lymph nodes relies on CCL21 chemokine sensing by CCR7 receptors, while exit into efferent lymphatics relies on sphingolipid S1P sensing by S1PR1 recep...

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Detalles Bibliográficos
Autores principales:	Garcia-Seyda, Nicolas, Song, Solene, Seveau de Noray, Valentine, David-Broglio, Luc, Matti, Christoph, Artinger, Marc, Dupuy, Florian, Biarnes-Pelicot, Martine, Valignat, Marie-Pierre, Legler, Daniel F., Bajénoff, Marc, Theodoly, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562802/ https://www.ncbi.nlm.nih.gov/pubmed/37822497 http://dx.doi.org/10.1016/j.isci.2023.107695

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