CD38 regulates ovarian function and fecundity via NAD(+) metabolism

Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show that CD38, an NAD+ consuming enzyme, is expressed in the ov...

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Detalles Bibliográficos
Autores principales: Perrone, Rosalba, Ashok Kumaar, Prasanna Vadhana, Haky, Lauren, Hahn, Cosmo, Riley, Rebeccah, Balough, Julia, Zaza, Giuliana, Soygur, Bikem, Hung, Kaitlyn, Prado, Leandro, Kasler, Herbert G., Tiwari, Ritesh, Matsui, Hiroyuki, Hormazabal, Genesis Vega, Heckenbach, Indra, Scheibye-Knudsen, Morten, Duncan, Francesca E., Verdin, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562803/
https://www.ncbi.nlm.nih.gov/pubmed/37822499
http://dx.doi.org/10.1016/j.isci.2023.107949

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