Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A

The synthesis of mono- and novel bis-methylated pyrrolo[1,2-a]quinoxalines through the addition of unstable methyl radicals to aryl isocyanides is described contingent upon the reaction conditions employed. The strategy has been effectively employed in the total synthesis of the natural product mari...

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Detalles Bibliográficos
Autores principales: Damai, Margarita, Guzzardi, Norman, Lewis, Viliyana, Rao, Zenobia X., Sykes, Daniel, Patel, Bhaven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562898/
https://www.ncbi.nlm.nih.gov/pubmed/37822662
http://dx.doi.org/10.1039/d3ra05952a
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author Damai, Margarita
Guzzardi, Norman
Lewis, Viliyana
Rao, Zenobia X.
Sykes, Daniel
Patel, Bhaven
author_facet Damai, Margarita
Guzzardi, Norman
Lewis, Viliyana
Rao, Zenobia X.
Sykes, Daniel
Patel, Bhaven
author_sort Damai, Margarita
collection PubMed
description The synthesis of mono- and novel bis-methylated pyrrolo[1,2-a]quinoxalines through the addition of unstable methyl radicals to aryl isocyanides is described contingent upon the reaction conditions employed. The strategy has been effectively employed in the total synthesis of the natural product marinoquinoline A.
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spelling pubmed-105628982023-10-11 Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A Damai, Margarita Guzzardi, Norman Lewis, Viliyana Rao, Zenobia X. Sykes, Daniel Patel, Bhaven RSC Adv Chemistry The synthesis of mono- and novel bis-methylated pyrrolo[1,2-a]quinoxalines through the addition of unstable methyl radicals to aryl isocyanides is described contingent upon the reaction conditions employed. The strategy has been effectively employed in the total synthesis of the natural product marinoquinoline A. The Royal Society of Chemistry 2023-10-10 /pmc/articles/PMC10562898/ /pubmed/37822662 http://dx.doi.org/10.1039/d3ra05952a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Damai, Margarita
Guzzardi, Norman
Lewis, Viliyana
Rao, Zenobia X.
Sykes, Daniel
Patel, Bhaven
Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A
title Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A
title_full Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A
title_fullStr Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A
title_full_unstemmed Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A
title_short Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A
title_sort crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline a
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562898/
https://www.ncbi.nlm.nih.gov/pubmed/37822662
http://dx.doi.org/10.1039/d3ra05952a
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