Immunization of children with inflammatory bowel disease against SARS-CoV-19 infection: A prospective single centre cohort study

BACKGROUND: Real-world data of children with inflammatory bowel disease (IBD) after SARS-CoV-2 vaccination are needed. METHOD: This prospective, observational study evaluate antibody kinetics of children with IBD 6 months after immunization with COVID-19 mRNA vaccine. RESULTS: 24 children with IBD w...

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Detalles Bibliográficos
Autores principales: Dohos, Dóra, Karoliny, Anna, Gombos, Eszter, Rimanóczy, Éva, Müller, Katalin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Short communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562902/
https://www.ncbi.nlm.nih.gov/pubmed/37822890
http://dx.doi.org/10.1016/j.jvacx.2023.100374
Descripción
Sumario:BACKGROUND: Real-world data of children with inflammatory bowel disease (IBD) after SARS-CoV-2 vaccination are needed. METHOD: This prospective, observational study evaluate antibody kinetics of children with IBD 6 months after immunization with COVID-19 mRNA vaccine. RESULTS: 24 children with IBD were included, 22 received immunosuppressive treatment. After five weeks the spike protein antibody level was positive in 95% of the cases. After six months all participants had seropositivity results, though the titre was decreasing. CONCLUSION: These data show the effectiveness of SARS-CoV2 immunization and the antibody decay over time, that highlight the importance of booster vaccines.

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