Immunization of children with inflammatory bowel disease against SARS-CoV-19 infection: A prospective single centre cohort study

BACKGROUND: Real-world data of children with inflammatory bowel disease (IBD) after SARS-CoV-2 vaccination are needed. METHOD: This prospective, observational study evaluate antibody kinetics of children with IBD 6 months after immunization with COVID-19 mRNA vaccine. RESULTS: 24 children with IBD w...

Descripción completa

Detalles Bibliográficos
Autores principales: Dohos, Dóra, Karoliny, Anna, Gombos, Eszter, Rimanóczy, Éva, Müller, Katalin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Short communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562902/
https://www.ncbi.nlm.nih.gov/pubmed/37822890
http://dx.doi.org/10.1016/j.jvacx.2023.100374
_version_ 1785118231543939072
author Dohos, Dóra
Karoliny, Anna
Gombos, Eszter
Rimanóczy, Éva
Müller, Katalin E.
author_facet Dohos, Dóra
Karoliny, Anna
Gombos, Eszter
Rimanóczy, Éva
Müller, Katalin E.
author_sort Dohos, Dóra
collection PubMed
description BACKGROUND: Real-world data of children with inflammatory bowel disease (IBD) after SARS-CoV-2 vaccination are needed. METHOD: This prospective, observational study evaluate antibody kinetics of children with IBD 6 months after immunization with COVID-19 mRNA vaccine. RESULTS: 24 children with IBD were included, 22 received immunosuppressive treatment. After five weeks the spike protein antibody level was positive in 95% of the cases. After six months all participants had seropositivity results, though the titre was decreasing. CONCLUSION: These data show the effectiveness of SARS-CoV2 immunization and the antibody decay over time, that highlight the importance of booster vaccines.
format Online
Article
Text
id pubmed-10562902
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-105629022023-10-11 Immunization of children with inflammatory bowel disease against SARS-CoV-19 infection: A prospective single centre cohort study Dohos, Dóra Karoliny, Anna Gombos, Eszter Rimanóczy, Éva Müller, Katalin E. Vaccine X Short communication BACKGROUND: Real-world data of children with inflammatory bowel disease (IBD) after SARS-CoV-2 vaccination are needed. METHOD: This prospective, observational study evaluate antibody kinetics of children with IBD 6 months after immunization with COVID-19 mRNA vaccine. RESULTS: 24 children with IBD were included, 22 received immunosuppressive treatment. After five weeks the spike protein antibody level was positive in 95% of the cases. After six months all participants had seropositivity results, though the titre was decreasing. CONCLUSION: These data show the effectiveness of SARS-CoV2 immunization and the antibody decay over time, that highlight the importance of booster vaccines. Elsevier 2023-08-19 /pmc/articles/PMC10562902/ /pubmed/37822890 http://dx.doi.org/10.1016/j.jvacx.2023.100374 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short communication
Dohos, Dóra
Karoliny, Anna
Gombos, Eszter
Rimanóczy, Éva
Müller, Katalin E.
Immunization of children with inflammatory bowel disease against SARS-CoV-19 infection: A prospective single centre cohort study
title Immunization of children with inflammatory bowel disease against SARS-CoV-19 infection: A prospective single centre cohort study
title_full Immunization of children with inflammatory bowel disease against SARS-CoV-19 infection: A prospective single centre cohort study
title_fullStr Immunization of children with inflammatory bowel disease against SARS-CoV-19 infection: A prospective single centre cohort study
title_full_unstemmed Immunization of children with inflammatory bowel disease against SARS-CoV-19 infection: A prospective single centre cohort study
title_short Immunization of children with inflammatory bowel disease against SARS-CoV-19 infection: A prospective single centre cohort study
title_sort immunization of children with inflammatory bowel disease against sars-cov-19 infection: a prospective single centre cohort study
topic Short communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562902/
https://www.ncbi.nlm.nih.gov/pubmed/37822890
http://dx.doi.org/10.1016/j.jvacx.2023.100374
work_keys_str_mv AT dohosdora immunizationofchildrenwithinflammatoryboweldiseaseagainstsarscov19infectionaprospectivesinglecentrecohortstudy
AT karolinyanna immunizationofchildrenwithinflammatoryboweldiseaseagainstsarscov19infectionaprospectivesinglecentrecohortstudy
AT gomboseszter immunizationofchildrenwithinflammatoryboweldiseaseagainstsarscov19infectionaprospectivesinglecentrecohortstudy
AT rimanoczyeva immunizationofchildrenwithinflammatoryboweldiseaseagainstsarscov19infectionaprospectivesinglecentrecohortstudy
AT mullerkataline immunizationofchildrenwithinflammatoryboweldiseaseagainstsarscov19infectionaprospectivesinglecentrecohortstudy

Ejemplares similares