Advancing Enzyme’s Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning

[Image: see text] Thermostability is an essential requirement for the use of enzymes in the bioindustry. Here, we compare different protein stabilization strategies using a challenging target, a stable haloalkane dehalogenase DhaA115. We observe better performance of automated stabilization platform...

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Detalles Bibliográficos
Autores principales: Kunka, Antonin, Marques, Sérgio M., Havlasek, Martin, Vasina, Michal, Velatova, Nikola, Cengelova, Lucia, Kovar, David, Damborsky, Jiri, Marek, Martin, Bednar, David, Prokop, Zbynek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563018/
https://www.ncbi.nlm.nih.gov/pubmed/37822856
http://dx.doi.org/10.1021/acscatal.3c02575

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