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SARS-CoV-2 spike variants differ in their allosteric responses to linoleic acid

The SARS-CoV-2 spike protein contains a functionally important fatty acid (FA) binding site, which is also found in some other coronaviruses, e.g. SARS-CoV and MERS-CoV. The occupancy of the FA site by linoleic acid (LA) reduces infectivity by ‘locking’ the spike in a less infectious conformation. H...

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Detalles Bibliográficos
Autores principales:	Oliveira, A Sofia F, Shoemark, Deborah K, Davidson, Andrew D, Berger, Imre, Schaffitzel, Christiane, Mulholland, Adrian J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563148/ https://www.ncbi.nlm.nih.gov/pubmed/36990513 http://dx.doi.org/10.1093/jmcb/mjad021

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