Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors

BACKGROUND: Seizures are associated with a decrease in γ-aminobutyric type A acid receptors (GABAaRs) on the neuronal surface, which may be regulated by enhanced internalization of GABAaRs. When interactions between GABAaR subunit α-1 (GABRA1) and postsynaptic scaffold proteins are weakened, the α1-...

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Detalles Bibliográficos
Autores principales: Li, Sijun, Wei, Xing, Huang, Hongmi, Ye, Lin, Ma, Meigang, Sun, Lanfeng, Lu, Yuling, Wu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563248/
https://www.ncbi.nlm.nih.gov/pubmed/37814294
http://dx.doi.org/10.1186/s12967-023-04596-4

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