Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration

BACKGROUND: Extracellular matrix stiffness is emerging as a crucial mechanical cue that drives the progression of various diseases, such as cancer, fibrosis, and inflammation. The matrix stiffness of the nucleus pulposus (NP) tissues increase gradually during intervertebral disc degeneration (IDD),...

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Detalles Bibliográficos
Autores principales: Ke, Wencan, Wang, Bingjin, Liao, Zhiwei, Song, Yu, Li, Gaocai, Ma, Liang, Wang, Kun, Li, Shuai, Hua, Wenbin, Yang, Cao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563269/
https://www.ncbi.nlm.nih.gov/pubmed/37817199
http://dx.doi.org/10.1186/s12967-023-04590-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563269/
https://www.ncbi.nlm.nih.gov/pubmed/37817199
http://dx.doi.org/10.1186/s12967-023-04590-w

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