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Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study

BACKGROUND: Myasthenia gravis (MG) affects individuals as a chronic autoimmune disease for many years. Commonly, chronic diseases significantly reduce the patients’ quality of life. Aiming to improve the future quality of life in MG, this study assessed the factors impacting quality of life. As gend...

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Autores principales: Wilcke, Hannah, Glaubitz, Stefanie, Kück, Fabian, Anten, Christoph, Liebetanz, David, Schmidt, Jens, Zschüntzsch, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563278/
https://www.ncbi.nlm.nih.gov/pubmed/37817097
http://dx.doi.org/10.1186/s12883-023-03406-0
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author Wilcke, Hannah
Glaubitz, Stefanie
Kück, Fabian
Anten, Christoph
Liebetanz, David
Schmidt, Jens
Zschüntzsch, Jana
author_facet Wilcke, Hannah
Glaubitz, Stefanie
Kück, Fabian
Anten, Christoph
Liebetanz, David
Schmidt, Jens
Zschüntzsch, Jana
author_sort Wilcke, Hannah
collection PubMed
description BACKGROUND: Myasthenia gravis (MG) affects individuals as a chronic autoimmune disease for many years. Commonly, chronic diseases significantly reduce the patients’ quality of life. Aiming to improve the future quality of life in MG, this study assessed the factors impacting quality of life. As gender-specific medicine is becoming increasingly important, this study also focused on understanding gender differences in the outcome of MG. METHODS: The study is a combined monocentric, retrospective and prospective database analysis of patient records based on 2,370 presentations of 165 patients with clinically, serologically and/or electrophysiologically confirmed MG over an observation period of up to 47 years. The data collection included the following parameters: antibody status, disease severity, age, medication use, gender, and disease duration. In addition, a prospective survey was conducted on the quality of life using the Myasthenia gravis-specific 15-item Quality of Life scale (MG-QoL15) and on the activities of daily living using the MG-specific Activities of Daily Living scale (MG-ADL). RESULTS: Of the 165 patients, 85 were male (51.5%) and 80 were female (48.5%). The remaining baseline characteristics (e.g. age and antibody status) were consistent with other myasthenia gravis cohorts. A high body mass index (BMI) (p = 0.005) and a high disease severity (p < 0.001) were significantly associated with lower disease-specific quality of life. Additionally, the quality of life in women with MG was significantly reduced compared to male patients (19.7 vs. 13.0 points in the MG-QoL15, p = 0.024). Gender differences were also observable in terms of the period between initial manifestation and initial diagnosis and women were significantly more impaired in their activities of daily living (MG-ADL) than men (4.8 vs. 3.0 points, p = 0.032). CONCLUSION: Women with MG had significantly poorer disease specific quality of life compared to men as well as patients with a higher BMI. In order to improve the quality of life, gender-specific medicine and further investigation regarding a modification of the quality of life by lowering the BMI are essential and necessary. TRIAL REGISTRATION: Study approval by the Ethics Committee of the University Medical Center Göttingen was granted (number 6/5/18).
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spelling pubmed-105632782023-10-11 Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study Wilcke, Hannah Glaubitz, Stefanie Kück, Fabian Anten, Christoph Liebetanz, David Schmidt, Jens Zschüntzsch, Jana BMC Neurol Research BACKGROUND: Myasthenia gravis (MG) affects individuals as a chronic autoimmune disease for many years. Commonly, chronic diseases significantly reduce the patients’ quality of life. Aiming to improve the future quality of life in MG, this study assessed the factors impacting quality of life. As gender-specific medicine is becoming increasingly important, this study also focused on understanding gender differences in the outcome of MG. METHODS: The study is a combined monocentric, retrospective and prospective database analysis of patient records based on 2,370 presentations of 165 patients with clinically, serologically and/or electrophysiologically confirmed MG over an observation period of up to 47 years. The data collection included the following parameters: antibody status, disease severity, age, medication use, gender, and disease duration. In addition, a prospective survey was conducted on the quality of life using the Myasthenia gravis-specific 15-item Quality of Life scale (MG-QoL15) and on the activities of daily living using the MG-specific Activities of Daily Living scale (MG-ADL). RESULTS: Of the 165 patients, 85 were male (51.5%) and 80 were female (48.5%). The remaining baseline characteristics (e.g. age and antibody status) were consistent with other myasthenia gravis cohorts. A high body mass index (BMI) (p = 0.005) and a high disease severity (p < 0.001) were significantly associated with lower disease-specific quality of life. Additionally, the quality of life in women with MG was significantly reduced compared to male patients (19.7 vs. 13.0 points in the MG-QoL15, p = 0.024). Gender differences were also observable in terms of the period between initial manifestation and initial diagnosis and women were significantly more impaired in their activities of daily living (MG-ADL) than men (4.8 vs. 3.0 points, p = 0.032). CONCLUSION: Women with MG had significantly poorer disease specific quality of life compared to men as well as patients with a higher BMI. In order to improve the quality of life, gender-specific medicine and further investigation regarding a modification of the quality of life by lowering the BMI are essential and necessary. TRIAL REGISTRATION: Study approval by the Ethics Committee of the University Medical Center Göttingen was granted (number 6/5/18). BioMed Central 2023-10-10 /pmc/articles/PMC10563278/ /pubmed/37817097 http://dx.doi.org/10.1186/s12883-023-03406-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wilcke, Hannah
Glaubitz, Stefanie
Kück, Fabian
Anten, Christoph
Liebetanz, David
Schmidt, Jens
Zschüntzsch, Jana
Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study
title Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study
title_full Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study
title_fullStr Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study
title_full_unstemmed Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study
title_short Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study
title_sort female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563278/
https://www.ncbi.nlm.nih.gov/pubmed/37817097
http://dx.doi.org/10.1186/s12883-023-03406-0
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