A dual role for adeno-associated virus in human health

Adeno-associated virus (AAV) differs from most other viruses, as it requires the simultaneous presence of a helper virus for an active infection. Up to 80% of the human population is seropositive for AAV antibodies. AAV has been known to be a non-pathogenic virus and an inhibitor of carcinogenesis c...

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Autor principal: Araujo, Natalia M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563340/
https://www.ncbi.nlm.nih.gov/pubmed/37817259
http://dx.doi.org/10.1186/s12985-023-02196-8
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author Araujo, Natalia M
author_facet Araujo, Natalia M
author_sort Araujo, Natalia M
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description Adeno-associated virus (AAV) differs from most other viruses, as it requires the simultaneous presence of a helper virus for an active infection. Up to 80% of the human population is seropositive for AAV antibodies. AAV has been known to be a non-pathogenic virus and an inhibitor of carcinogenesis caused by coinfecting viruses. However, the recent reports associating AAV infection with hepatocellular carcinoma development and the mysterious cases of acute severe hepatitis in children have challenged the idea that AAV is a harmless virus. Herein, we explore the usefulness of AAV in gene therapy and the importance of AAV as a protector or perpetrator in human carcinogenesis, ultimately reflecting on the dual role of AAV in human health.
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spelling pubmed-105633402023-10-11 A dual role for adeno-associated virus in human health Araujo, Natalia M Virol J Comment Adeno-associated virus (AAV) differs from most other viruses, as it requires the simultaneous presence of a helper virus for an active infection. Up to 80% of the human population is seropositive for AAV antibodies. AAV has been known to be a non-pathogenic virus and an inhibitor of carcinogenesis caused by coinfecting viruses. However, the recent reports associating AAV infection with hepatocellular carcinoma development and the mysterious cases of acute severe hepatitis in children have challenged the idea that AAV is a harmless virus. Herein, we explore the usefulness of AAV in gene therapy and the importance of AAV as a protector or perpetrator in human carcinogenesis, ultimately reflecting on the dual role of AAV in human health. BioMed Central 2023-10-10 /pmc/articles/PMC10563340/ /pubmed/37817259 http://dx.doi.org/10.1186/s12985-023-02196-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Comment
Araujo, Natalia M
A dual role for adeno-associated virus in human health
title A dual role for adeno-associated virus in human health
title_full A dual role for adeno-associated virus in human health
title_fullStr A dual role for adeno-associated virus in human health
title_full_unstemmed A dual role for adeno-associated virus in human health
title_short A dual role for adeno-associated virus in human health
title_sort dual role for adeno-associated virus in human health
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563340/
https://www.ncbi.nlm.nih.gov/pubmed/37817259
http://dx.doi.org/10.1186/s12985-023-02196-8
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