Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection

BACKGROUND: Tedizolid is a new oxazolidinone antibiotic with high potency for the treatment of infections caused by methicillin-resistant Staphylococcus aureus and other species. CASE PRESENTATION: Two patients with osteoarthritis (women aged 79 and 73 years, cases 1 and 2, respectively) infected wi...

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Autores principales: Negishi, Daisuke, Mitsumatsu, Okimichi, Mitsumatsu, Hiromi, Makiguchi, Miaki, Shimizu, Makiko, Yamazaki, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563349/
https://www.ncbi.nlm.nih.gov/pubmed/37814345
http://dx.doi.org/10.1186/s40780-023-00303-z
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author Negishi, Daisuke
Mitsumatsu, Okimichi
Mitsumatsu, Hiromi
Makiguchi, Miaki
Shimizu, Makiko
Yamazaki, Hiroshi
author_facet Negishi, Daisuke
Mitsumatsu, Okimichi
Mitsumatsu, Hiromi
Makiguchi, Miaki
Shimizu, Makiko
Yamazaki, Hiroshi
author_sort Negishi, Daisuke
collection PubMed
description BACKGROUND: Tedizolid is a new oxazolidinone antibiotic with high potency for the treatment of infections caused by methicillin-resistant Staphylococcus aureus and other species. CASE PRESENTATION: Two patients with osteoarthritis (women aged 79 and 73 years, cases 1 and 2, respectively) infected with S. aureus were successfully treated with tedizolid after administration of 200 mg once daily via intravenous infusion. The synovial fluid and plasma concentrations of tedizolid during surgery in case 1 at day 7 were 2.1 and 1.6 µg/mL, respectively, yielding a ratio of synovial fluid/plasma of 130%. Those in case 2 at day 2 were 2.9 and 3.3 µg/mL, respectively, corresponding to a ratio of synovial fluid/plasma of 88%. CONCLUSIONS: These results imply very similar concentrations of tedizolid in the synovial fluid and plasma of osteoarthritis patients with acute S. aureus infection.
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spelling pubmed-105633492023-10-11 Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection Negishi, Daisuke Mitsumatsu, Okimichi Mitsumatsu, Hiromi Makiguchi, Miaki Shimizu, Makiko Yamazaki, Hiroshi J Pharm Health Care Sci Case Report BACKGROUND: Tedizolid is a new oxazolidinone antibiotic with high potency for the treatment of infections caused by methicillin-resistant Staphylococcus aureus and other species. CASE PRESENTATION: Two patients with osteoarthritis (women aged 79 and 73 years, cases 1 and 2, respectively) infected with S. aureus were successfully treated with tedizolid after administration of 200 mg once daily via intravenous infusion. The synovial fluid and plasma concentrations of tedizolid during surgery in case 1 at day 7 were 2.1 and 1.6 µg/mL, respectively, yielding a ratio of synovial fluid/plasma of 130%. Those in case 2 at day 2 were 2.9 and 3.3 µg/mL, respectively, corresponding to a ratio of synovial fluid/plasma of 88%. CONCLUSIONS: These results imply very similar concentrations of tedizolid in the synovial fluid and plasma of osteoarthritis patients with acute S. aureus infection. BioMed Central 2023-10-10 /pmc/articles/PMC10563349/ /pubmed/37814345 http://dx.doi.org/10.1186/s40780-023-00303-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Negishi, Daisuke
Mitsumatsu, Okimichi
Mitsumatsu, Hiromi
Makiguchi, Miaki
Shimizu, Makiko
Yamazaki, Hiroshi
Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection
title Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection
title_full Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection
title_fullStr Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection
title_full_unstemmed Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection
title_short Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection
title_sort synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with staphylococcus aureus effectively determined with fluorescence detection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563349/
https://www.ncbi.nlm.nih.gov/pubmed/37814345
http://dx.doi.org/10.1186/s40780-023-00303-z
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