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Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study

AIMS: Heart failure (HF) is a major health problem and early diagnosis is important. Atherosclerosis is the main cause of HF and carotid intima-media thickness (IMT) is a recognized early measure of atherosclerosis. This study aimed to investigate whether increased carotid IMT is associated with cha...

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Autores principales: Simon, Judit, Fung, Kenneth, Raisi-Estabragh, Zahra, Aung, Nay, Khanji, Mohammed Y, Zsarnóczay, Emese, Merkely, Béla, Munroe, Patricia B, Harvey, Nicholas C, Piechnik, Stefan K, Neubauer, Stefan, Leeson, Paul, Petersen, Steffen E, Maurovich-Horvat, Pál
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563379/
https://www.ncbi.nlm.nih.gov/pubmed/37822973
http://dx.doi.org/10.1093/ehjimp/qyad010
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author Simon, Judit
Fung, Kenneth
Raisi-Estabragh, Zahra
Aung, Nay
Khanji, Mohammed Y
Zsarnóczay, Emese
Merkely, Béla
Munroe, Patricia B
Harvey, Nicholas C
Piechnik, Stefan K
Neubauer, Stefan
Leeson, Paul
Petersen, Steffen E
Maurovich-Horvat, Pál
author_facet Simon, Judit
Fung, Kenneth
Raisi-Estabragh, Zahra
Aung, Nay
Khanji, Mohammed Y
Zsarnóczay, Emese
Merkely, Béla
Munroe, Patricia B
Harvey, Nicholas C
Piechnik, Stefan K
Neubauer, Stefan
Leeson, Paul
Petersen, Steffen E
Maurovich-Horvat, Pál
author_sort Simon, Judit
collection PubMed
description AIMS: Heart failure (HF) is a major health problem and early diagnosis is important. Atherosclerosis is the main cause of HF and carotid intima-media thickness (IMT) is a recognized early measure of atherosclerosis. This study aimed to investigate whether increased carotid IMT is associated with changes in cardiac structure and function in middle-aged participants of the UK Biobank Study without overt cardiovascular disease. METHODS AND RESULTS: Participants of the UK Biobank who underwent CMR and carotid ultrasound examinations were included in this study. Patients with heart failure, angina, atrial fibrillation, and history of myocardial infarction or stroke were excluded. We used multivariable linear regression models adjusted for age, sex, physical activity, body mass index, body surface area, hypertension, diabetes, smoking, ethnicity, socioeconomic status, alcohol intake, and laboratory parameters. In total, 4301 individuals (61.6 ± 7.5 years, 45.9% male) were included. Multivariable linear regression analyses showed that increasing quartiles of IMT was associated with increased left and right ventricular (LV and RV) and left atrial volumes and greater LV mass. Moreover, increased IMT was related to lower LV end-systolic circumferential strain, torsion, and both left and right atrial ejection fractions (all P < 0.05). CONCLUSION: Increased IMT showed an independent association over traditional risk factors with enlargement of all four cardiac chambers, decreased function in both atria, greater LV mass, and subclinical LV dysfunction. There may be additional risk stratification that can be derived from the IMT to identify those most likely to have early cardiac structural/functional changes.
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spelling pubmed-105633792023-10-11 Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study Simon, Judit Fung, Kenneth Raisi-Estabragh, Zahra Aung, Nay Khanji, Mohammed Y Zsarnóczay, Emese Merkely, Béla Munroe, Patricia B Harvey, Nicholas C Piechnik, Stefan K Neubauer, Stefan Leeson, Paul Petersen, Steffen E Maurovich-Horvat, Pál Eur Heart J Imaging Methods Pract Original Article AIMS: Heart failure (HF) is a major health problem and early diagnosis is important. Atherosclerosis is the main cause of HF and carotid intima-media thickness (IMT) is a recognized early measure of atherosclerosis. This study aimed to investigate whether increased carotid IMT is associated with changes in cardiac structure and function in middle-aged participants of the UK Biobank Study without overt cardiovascular disease. METHODS AND RESULTS: Participants of the UK Biobank who underwent CMR and carotid ultrasound examinations were included in this study. Patients with heart failure, angina, atrial fibrillation, and history of myocardial infarction or stroke were excluded. We used multivariable linear regression models adjusted for age, sex, physical activity, body mass index, body surface area, hypertension, diabetes, smoking, ethnicity, socioeconomic status, alcohol intake, and laboratory parameters. In total, 4301 individuals (61.6 ± 7.5 years, 45.9% male) were included. Multivariable linear regression analyses showed that increasing quartiles of IMT was associated with increased left and right ventricular (LV and RV) and left atrial volumes and greater LV mass. Moreover, increased IMT was related to lower LV end-systolic circumferential strain, torsion, and both left and right atrial ejection fractions (all P < 0.05). CONCLUSION: Increased IMT showed an independent association over traditional risk factors with enlargement of all four cardiac chambers, decreased function in both atria, greater LV mass, and subclinical LV dysfunction. There may be additional risk stratification that can be derived from the IMT to identify those most likely to have early cardiac structural/functional changes. Oxford University Press 2023-09-19 /pmc/articles/PMC10563379/ /pubmed/37822973 http://dx.doi.org/10.1093/ehjimp/qyad010 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Simon, Judit
Fung, Kenneth
Raisi-Estabragh, Zahra
Aung, Nay
Khanji, Mohammed Y
Zsarnóczay, Emese
Merkely, Béla
Munroe, Patricia B
Harvey, Nicholas C
Piechnik, Stefan K
Neubauer, Stefan
Leeson, Paul
Petersen, Steffen E
Maurovich-Horvat, Pál
Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study
title Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study
title_full Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study
title_fullStr Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study
title_full_unstemmed Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study
title_short Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study
title_sort association between subclinical atherosclerosis and cardiac structure and function—results from the uk biobank study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563379/
https://www.ncbi.nlm.nih.gov/pubmed/37822973
http://dx.doi.org/10.1093/ehjimp/qyad010
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