Cargando…
Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study
AIMS: Heart failure (HF) is a major health problem and early diagnosis is important. Atherosclerosis is the main cause of HF and carotid intima-media thickness (IMT) is a recognized early measure of atherosclerosis. This study aimed to investigate whether increased carotid IMT is associated with cha...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563379/ https://www.ncbi.nlm.nih.gov/pubmed/37822973 http://dx.doi.org/10.1093/ehjimp/qyad010 |
_version_ | 1785118328544559104 |
---|---|
author | Simon, Judit Fung, Kenneth Raisi-Estabragh, Zahra Aung, Nay Khanji, Mohammed Y Zsarnóczay, Emese Merkely, Béla Munroe, Patricia B Harvey, Nicholas C Piechnik, Stefan K Neubauer, Stefan Leeson, Paul Petersen, Steffen E Maurovich-Horvat, Pál |
author_facet | Simon, Judit Fung, Kenneth Raisi-Estabragh, Zahra Aung, Nay Khanji, Mohammed Y Zsarnóczay, Emese Merkely, Béla Munroe, Patricia B Harvey, Nicholas C Piechnik, Stefan K Neubauer, Stefan Leeson, Paul Petersen, Steffen E Maurovich-Horvat, Pál |
author_sort | Simon, Judit |
collection | PubMed |
description | AIMS: Heart failure (HF) is a major health problem and early diagnosis is important. Atherosclerosis is the main cause of HF and carotid intima-media thickness (IMT) is a recognized early measure of atherosclerosis. This study aimed to investigate whether increased carotid IMT is associated with changes in cardiac structure and function in middle-aged participants of the UK Biobank Study without overt cardiovascular disease. METHODS AND RESULTS: Participants of the UK Biobank who underwent CMR and carotid ultrasound examinations were included in this study. Patients with heart failure, angina, atrial fibrillation, and history of myocardial infarction or stroke were excluded. We used multivariable linear regression models adjusted for age, sex, physical activity, body mass index, body surface area, hypertension, diabetes, smoking, ethnicity, socioeconomic status, alcohol intake, and laboratory parameters. In total, 4301 individuals (61.6 ± 7.5 years, 45.9% male) were included. Multivariable linear regression analyses showed that increasing quartiles of IMT was associated with increased left and right ventricular (LV and RV) and left atrial volumes and greater LV mass. Moreover, increased IMT was related to lower LV end-systolic circumferential strain, torsion, and both left and right atrial ejection fractions (all P < 0.05). CONCLUSION: Increased IMT showed an independent association over traditional risk factors with enlargement of all four cardiac chambers, decreased function in both atria, greater LV mass, and subclinical LV dysfunction. There may be additional risk stratification that can be derived from the IMT to identify those most likely to have early cardiac structural/functional changes. |
format | Online Article Text |
id | pubmed-10563379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105633792023-10-11 Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study Simon, Judit Fung, Kenneth Raisi-Estabragh, Zahra Aung, Nay Khanji, Mohammed Y Zsarnóczay, Emese Merkely, Béla Munroe, Patricia B Harvey, Nicholas C Piechnik, Stefan K Neubauer, Stefan Leeson, Paul Petersen, Steffen E Maurovich-Horvat, Pál Eur Heart J Imaging Methods Pract Original Article AIMS: Heart failure (HF) is a major health problem and early diagnosis is important. Atherosclerosis is the main cause of HF and carotid intima-media thickness (IMT) is a recognized early measure of atherosclerosis. This study aimed to investigate whether increased carotid IMT is associated with changes in cardiac structure and function in middle-aged participants of the UK Biobank Study without overt cardiovascular disease. METHODS AND RESULTS: Participants of the UK Biobank who underwent CMR and carotid ultrasound examinations were included in this study. Patients with heart failure, angina, atrial fibrillation, and history of myocardial infarction or stroke were excluded. We used multivariable linear regression models adjusted for age, sex, physical activity, body mass index, body surface area, hypertension, diabetes, smoking, ethnicity, socioeconomic status, alcohol intake, and laboratory parameters. In total, 4301 individuals (61.6 ± 7.5 years, 45.9% male) were included. Multivariable linear regression analyses showed that increasing quartiles of IMT was associated with increased left and right ventricular (LV and RV) and left atrial volumes and greater LV mass. Moreover, increased IMT was related to lower LV end-systolic circumferential strain, torsion, and both left and right atrial ejection fractions (all P < 0.05). CONCLUSION: Increased IMT showed an independent association over traditional risk factors with enlargement of all four cardiac chambers, decreased function in both atria, greater LV mass, and subclinical LV dysfunction. There may be additional risk stratification that can be derived from the IMT to identify those most likely to have early cardiac structural/functional changes. Oxford University Press 2023-09-19 /pmc/articles/PMC10563379/ /pubmed/37822973 http://dx.doi.org/10.1093/ehjimp/qyad010 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Simon, Judit Fung, Kenneth Raisi-Estabragh, Zahra Aung, Nay Khanji, Mohammed Y Zsarnóczay, Emese Merkely, Béla Munroe, Patricia B Harvey, Nicholas C Piechnik, Stefan K Neubauer, Stefan Leeson, Paul Petersen, Steffen E Maurovich-Horvat, Pál Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study |
title | Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study |
title_full | Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study |
title_fullStr | Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study |
title_full_unstemmed | Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study |
title_short | Association between subclinical atherosclerosis and cardiac structure and function—results from the UK Biobank Study |
title_sort | association between subclinical atherosclerosis and cardiac structure and function—results from the uk biobank study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563379/ https://www.ncbi.nlm.nih.gov/pubmed/37822973 http://dx.doi.org/10.1093/ehjimp/qyad010 |
work_keys_str_mv | AT simonjudit associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT fungkenneth associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT raisiestabraghzahra associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT aungnay associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT khanjimohammedy associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT zsarnoczayemese associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT merkelybela associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT munroepatriciab associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT harveynicholasc associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT piechnikstefank associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT neubauerstefan associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT leesonpaul associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT petersensteffene associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy AT maurovichhorvatpal associationbetweensubclinicalatherosclerosisandcardiacstructureandfunctionresultsfromtheukbiobankstudy |