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Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study

While each place on the cochlea is most sensitive to a specific frequency, it will generally respond to a sufficiently high-level stimulus over a wide range of frequencies. This spread of excitation can introduce errors in clinical threshold estimation during a diagnostic auditory brainstem response...

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Autores principales: Stoll, Thomas J., Maddox, Ross K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563492/
https://www.ncbi.nlm.nih.gov/pubmed/37807857
http://dx.doi.org/10.1177/23312165231205719
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author Stoll, Thomas J.
Maddox, Ross K.
author_facet Stoll, Thomas J.
Maddox, Ross K.
author_sort Stoll, Thomas J.
collection PubMed
description While each place on the cochlea is most sensitive to a specific frequency, it will generally respond to a sufficiently high-level stimulus over a wide range of frequencies. This spread of excitation can introduce errors in clinical threshold estimation during a diagnostic auditory brainstem response (ABR) exam. Off-frequency cochlear excitation can be mitigated through the addition of masking noise to the test stimuli, but introducing a masker increases the already long test times of the typical ABR exam. Our lab has recently developed the parallel ABR (pABR) paradigm to speed up test times by utilizing randomized stimulus timing to estimate the thresholds for multiple frequencies simultaneously. There is reason to believe parallel presentation of multiple frequencies provides masking effects and improves place specificity while decreasing test times. Here, we use two computational models of the auditory periphery to characterize the predicted effect of parallel presentation on place specificity in the auditory nerve. We additionally examine the effect of stimulus rate and level. Both models show the pABR is at least as place specific as standard methods, with an improvement in place specificity for parallel presentation (vs. serial) at high levels, especially at high stimulus rates. When simulating hearing impairment in one of the models, place specificity was also improved near threshold. Rather than a tradeoff, this improved place specificity would represent a secondary benefit to the pABR's faster test times.
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spelling pubmed-105634922023-10-11 Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study Stoll, Thomas J. Maddox, Ross K. Trends Hear (S1) Original Article While each place on the cochlea is most sensitive to a specific frequency, it will generally respond to a sufficiently high-level stimulus over a wide range of frequencies. This spread of excitation can introduce errors in clinical threshold estimation during a diagnostic auditory brainstem response (ABR) exam. Off-frequency cochlear excitation can be mitigated through the addition of masking noise to the test stimuli, but introducing a masker increases the already long test times of the typical ABR exam. Our lab has recently developed the parallel ABR (pABR) paradigm to speed up test times by utilizing randomized stimulus timing to estimate the thresholds for multiple frequencies simultaneously. There is reason to believe parallel presentation of multiple frequencies provides masking effects and improves place specificity while decreasing test times. Here, we use two computational models of the auditory periphery to characterize the predicted effect of parallel presentation on place specificity in the auditory nerve. We additionally examine the effect of stimulus rate and level. Both models show the pABR is at least as place specific as standard methods, with an improvement in place specificity for parallel presentation (vs. serial) at high levels, especially at high stimulus rates. When simulating hearing impairment in one of the models, place specificity was also improved near threshold. Rather than a tradeoff, this improved place specificity would represent a secondary benefit to the pABR's faster test times. SAGE Publications 2023-10-09 /pmc/articles/PMC10563492/ /pubmed/37807857 http://dx.doi.org/10.1177/23312165231205719 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle (S1) Original Article
Stoll, Thomas J.
Maddox, Ross K.
Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study
title Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study
title_full Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study
title_fullStr Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study
title_full_unstemmed Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study
title_short Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study
title_sort enhanced place specificity of the parallel auditory brainstem response: a modeling study
topic (S1) Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563492/
https://www.ncbi.nlm.nih.gov/pubmed/37807857
http://dx.doi.org/10.1177/23312165231205719
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