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Association between intoxication with psychoactive substances and adverse effects occurrence in consumers

BACKGROUND: The prevalence of psychoactive substance use is increasing worldwide and identifying adverse effects of these types of drugs is necessary in intoxicated patients. OBJECTIVE: We aimed to investigate the association of psychoactive substance intoxication with their adverse effects on the f...

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Autores principales: Amanollahi, Alireza, Shadnia, Shahin, Mehrabi, Yadollah, Etemad, Koorosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563510/
https://www.ncbi.nlm.nih.gov/pubmed/37822541
http://dx.doi.org/10.3389/fpubh.2023.1228854
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author Amanollahi, Alireza
Shadnia, Shahin
Mehrabi, Yadollah
Etemad, Koorosh
author_facet Amanollahi, Alireza
Shadnia, Shahin
Mehrabi, Yadollah
Etemad, Koorosh
author_sort Amanollahi, Alireza
collection PubMed
description BACKGROUND: The prevalence of psychoactive substance use is increasing worldwide and identifying adverse effects of these types of drugs is necessary in intoxicated patients. OBJECTIVE: We aimed to investigate the association of psychoactive substance intoxication with their adverse effects on the functioning of the bodily organs. METHODS: This was a single-center study between March 2019 and April 2022 on intoxicated patients with psychoactive substances. Inclusion criteria were intoxication with alcohol, opioids, and stimulants, and having available results of laboratory biomarkers. Demographic and clinical data of patients at the time of admission as well as during hospitalization were reviewed, retrospectively. Data were analyzed using a generalized linear mixed model in R software and the Adjusted Odds Ratio (AOR) was estimated. RESULTS: A total of 800 hospitalized patients in the ICU (n = 400) and general ward (n = 400) were divided into two groups of intoxicated with alcohol (n = 200) and opioids or stimulants (n = 200). Liver (AOR = 0.15, p = 0.033; AOR = 0.13, p = 0.007) and kidney (AOR = 0.46, p = 0.004; AOR = 0.24, p = 0.021) dysfunction occurred less in the ICU and general ward, respectively, in opioids or stimulants intoxication compared to alcohol. Cardiovascular dysfunctions occurred more in opioids or stimulants intoxication compared to alcohol in both ICU (AOR = 10.32, p < 0.0001) and general ward (AOR = 4.74, p < 0.0001). CONCLUSION: Kidney dysfunctions had a greater effect on mortality compared to other dysfunctions. During the follow-up, the incidence of dysfunctions increased in those intoxicated with opioids or stimulants. Men experienced more liver and kidney dysfunctions as well as mortality, but psychoactive substance experience was a protective factor in cardiovascular dysfunctions and mortality.
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spelling pubmed-105635102023-10-11 Association between intoxication with psychoactive substances and adverse effects occurrence in consumers Amanollahi, Alireza Shadnia, Shahin Mehrabi, Yadollah Etemad, Koorosh Front Public Health Public Health BACKGROUND: The prevalence of psychoactive substance use is increasing worldwide and identifying adverse effects of these types of drugs is necessary in intoxicated patients. OBJECTIVE: We aimed to investigate the association of psychoactive substance intoxication with their adverse effects on the functioning of the bodily organs. METHODS: This was a single-center study between March 2019 and April 2022 on intoxicated patients with psychoactive substances. Inclusion criteria were intoxication with alcohol, opioids, and stimulants, and having available results of laboratory biomarkers. Demographic and clinical data of patients at the time of admission as well as during hospitalization were reviewed, retrospectively. Data were analyzed using a generalized linear mixed model in R software and the Adjusted Odds Ratio (AOR) was estimated. RESULTS: A total of 800 hospitalized patients in the ICU (n = 400) and general ward (n = 400) were divided into two groups of intoxicated with alcohol (n = 200) and opioids or stimulants (n = 200). Liver (AOR = 0.15, p = 0.033; AOR = 0.13, p = 0.007) and kidney (AOR = 0.46, p = 0.004; AOR = 0.24, p = 0.021) dysfunction occurred less in the ICU and general ward, respectively, in opioids or stimulants intoxication compared to alcohol. Cardiovascular dysfunctions occurred more in opioids or stimulants intoxication compared to alcohol in both ICU (AOR = 10.32, p < 0.0001) and general ward (AOR = 4.74, p < 0.0001). CONCLUSION: Kidney dysfunctions had a greater effect on mortality compared to other dysfunctions. During the follow-up, the incidence of dysfunctions increased in those intoxicated with opioids or stimulants. Men experienced more liver and kidney dysfunctions as well as mortality, but psychoactive substance experience was a protective factor in cardiovascular dysfunctions and mortality. Frontiers Media S.A. 2023-09-25 /pmc/articles/PMC10563510/ /pubmed/37822541 http://dx.doi.org/10.3389/fpubh.2023.1228854 Text en Copyright © 2023 Amanollahi, Shadnia, Mehrabi and Etemad. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Amanollahi, Alireza
Shadnia, Shahin
Mehrabi, Yadollah
Etemad, Koorosh
Association between intoxication with psychoactive substances and adverse effects occurrence in consumers
title Association between intoxication with psychoactive substances and adverse effects occurrence in consumers
title_full Association between intoxication with psychoactive substances and adverse effects occurrence in consumers
title_fullStr Association between intoxication with psychoactive substances and adverse effects occurrence in consumers
title_full_unstemmed Association between intoxication with psychoactive substances and adverse effects occurrence in consumers
title_short Association between intoxication with psychoactive substances and adverse effects occurrence in consumers
title_sort association between intoxication with psychoactive substances and adverse effects occurrence in consumers
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563510/
https://www.ncbi.nlm.nih.gov/pubmed/37822541
http://dx.doi.org/10.3389/fpubh.2023.1228854
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