SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients

The identification and characterization of plasma proteins in drug resistant and drug sensitive in HIV-1 infected/AIDS patients were carried out using the SWATH-MS protocol. In total, 204 proteins were identified and quantified, 57 proteins were differentially expressed, out of which 25 proteins wer...

Descripción completa

Detalles Bibliográficos
Autores principales: Barik, Sushanta Kumar, Tripathy, Srikanth Prasad, Bisht, Deepa, Singh, Praveen, Chakraborty, Rahul, Patil, Shripad A, Singh, Tej Pal, Varshney, Deepika, Jena, Srikanta, Mohanty, Keshar Kunja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563564/
https://www.ncbi.nlm.nih.gov/pubmed/37822814
http://dx.doi.org/10.6026/97320630019392
Descripción
Sumario:The identification and characterization of plasma proteins in drug resistant and drug sensitive in HIV-1 infected/AIDS patients were carried out using the SWATH-MS protocol. In total, 204 proteins were identified and quantified, 57 proteins were differentially expressed, out of which 25 proteins were down regulated and 32 proteins were up regulated in drug resistant patients. Six proteins such as complement C4-A, immunoglobulin heavy variable 1-2, carboxylic ester hydrolase, fibulin-1, immunoglobulin lambda constant7, secreted phosphoprotein 24 were differentially expressed in individuals with drug resistant HIV as compared to individuals with drug sensitive HIV. Gene ontology of 57 differentially expressed proteins was analysed and documented.

Ejemplares similares