SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients

The identification and characterization of plasma proteins in drug resistant and drug sensitive in HIV-1 infected/AIDS patients were carried out using the SWATH-MS protocol. In total, 204 proteins were identified and quantified, 57 proteins were differentially expressed, out of which 25 proteins wer...

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Autores principales: Barik, Sushanta Kumar, Tripathy, Srikanth Prasad, Bisht, Deepa, Singh, Praveen, Chakraborty, Rahul, Patil, Shripad A, Singh, Tej Pal, Varshney, Deepika, Jena, Srikanta, Mohanty, Keshar Kunja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563564/
https://www.ncbi.nlm.nih.gov/pubmed/37822814
http://dx.doi.org/10.6026/97320630019392
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author Barik, Sushanta Kumar
Tripathy, Srikanth Prasad
Bisht, Deepa
Singh, Praveen
Chakraborty, Rahul
Patil, Shripad A
Singh, Tej Pal
Varshney, Deepika
Jena, Srikanta
Mohanty, Keshar Kunja
author_facet Barik, Sushanta Kumar
Tripathy, Srikanth Prasad
Bisht, Deepa
Singh, Praveen
Chakraborty, Rahul
Patil, Shripad A
Singh, Tej Pal
Varshney, Deepika
Jena, Srikanta
Mohanty, Keshar Kunja
author_sort Barik, Sushanta Kumar
collection PubMed
description The identification and characterization of plasma proteins in drug resistant and drug sensitive in HIV-1 infected/AIDS patients were carried out using the SWATH-MS protocol. In total, 204 proteins were identified and quantified, 57 proteins were differentially expressed, out of which 25 proteins were down regulated and 32 proteins were up regulated in drug resistant patients. Six proteins such as complement C4-A, immunoglobulin heavy variable 1-2, carboxylic ester hydrolase, fibulin-1, immunoglobulin lambda constant7, secreted phosphoprotein 24 were differentially expressed in individuals with drug resistant HIV as compared to individuals with drug sensitive HIV. Gene ontology of 57 differentially expressed proteins was analysed and documented.
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spelling pubmed-105635642023-10-11 SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients Barik, Sushanta Kumar Tripathy, Srikanth Prasad Bisht, Deepa Singh, Praveen Chakraborty, Rahul Patil, Shripad A Singh, Tej Pal Varshney, Deepika Jena, Srikanta Mohanty, Keshar Kunja Bioinformation Research Article The identification and characterization of plasma proteins in drug resistant and drug sensitive in HIV-1 infected/AIDS patients were carried out using the SWATH-MS protocol. In total, 204 proteins were identified and quantified, 57 proteins were differentially expressed, out of which 25 proteins were down regulated and 32 proteins were up regulated in drug resistant patients. Six proteins such as complement C4-A, immunoglobulin heavy variable 1-2, carboxylic ester hydrolase, fibulin-1, immunoglobulin lambda constant7, secreted phosphoprotein 24 were differentially expressed in individuals with drug resistant HIV as compared to individuals with drug sensitive HIV. Gene ontology of 57 differentially expressed proteins was analysed and documented. Biomedical Informatics 2023-04-30 /pmc/articles/PMC10563564/ /pubmed/37822814 http://dx.doi.org/10.6026/97320630019392 Text en © 2023 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Barik, Sushanta Kumar
Tripathy, Srikanth Prasad
Bisht, Deepa
Singh, Praveen
Chakraborty, Rahul
Patil, Shripad A
Singh, Tej Pal
Varshney, Deepika
Jena, Srikanta
Mohanty, Keshar Kunja
SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients
title SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients
title_full SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients
title_fullStr SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients
title_full_unstemmed SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients
title_short SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients
title_sort swath-ms analysis of plasma proteins among indian hiv-1 infected patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563564/
https://www.ncbi.nlm.nih.gov/pubmed/37822814
http://dx.doi.org/10.6026/97320630019392
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