Molecular docking analysis of proflavin with the Wnt pathway targets for OSCC

Wnt signaling pathway plays a critical role in tumor progression and metastasis of various cancer types. Therefore, it is of interest to document the molecular docking analysis of proflavin with the Wnt pathway targets (GSK3β, β-catenin, and VIM) for oral squamous cell carcinoma (OSCC). These result...

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Detalles Bibliográficos
Autores principales: Pazhani, Jayanthi, Veeraraghavan, Vishnu Priya, Jayaraman, Selvaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563574/
https://www.ncbi.nlm.nih.gov/pubmed/37822816
http://dx.doi.org/10.6026/97320630019464
Descripción
Sumario:Wnt signaling pathway plays a critical role in tumor progression and metastasis of various cancer types. Therefore, it is of interest to document the molecular docking analysis of proflavin with the Wnt pathway targets (GSK3β, β-catenin, and VIM) for oral squamous cell carcinoma (OSCC). These results suggest that targeting the wnt signaling downstream targets with proflavine might leads to the better outcome for therapeutic outcome for the inhibition of invasion and metastasis in oral squamous cell carcinoma.

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