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Role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among Indians
Diabetic nephropathy/diabetic kidney disease (DKD) is one of the leading causes of renal failure. Early identification of the development or progression of diabetic nephropathy using appropriate screening and diagnostic tools is very important in order to provide timely and proper management. Inflam...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Biomedical Informatics
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563576/ https://www.ncbi.nlm.nih.gov/pubmed/37822815 http://dx.doi.org/10.6026/97320630019375 |
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author | Subramani, Murugan Anbarasan, Mudali Shanmugam, Deepalatha Muthumani, Lakshmi Narayanan Vasudevan, Pradeep |
author_facet | Subramani, Murugan Anbarasan, Mudali Shanmugam, Deepalatha Muthumani, Lakshmi Narayanan Vasudevan, Pradeep |
author_sort | Subramani, Murugan |
collection | PubMed |
description | Diabetic nephropathy/diabetic kidney disease (DKD) is one of the leading causes of renal failure. Early identification of the development or progression of diabetic nephropathy using appropriate screening and diagnostic tools is very important in order to provide timely and proper management. Inflammation plays a crucial role in development and progression of diabetic nephropathy. The aim of this study was to evaluate the relationship of inflammatory markers (neutrophil-to-lymphocyte ratio-NLR) as an early indicator to prevent the progression of diabetic kidney disease. A total of 158 patients with type 2 diabetes mellitus were distributed into three groups according urinary albumin-to-creatinine ratio. Levels of inflammatory markers neutrophil-to-lymphocyte ratio was recorded and compared among the three groups. Significant differences were detected between the groups in terms of neutrophil-to-lymphocyte ratio (p = 0.000).Characteristic curve analysis of inflammatory markers and microalbuminuria prediction demonstrated an area under curve (AUC) of 0.869 for neutrophil-to-lymphocyte ratio (p = 0.000). A NLR cut-off point of 2.2 has 72.3 % sensitivity and 78.1 % specificity, which suggested sufficient accuracy. Increased neutrophil-to-lymphocyte ratio was significantly correlated with diabetic nephropathy progression and increased neutrophil-to-lymphocyte ratio can be considered as an early indicator and a prognostic risk marker of diabetic nephropathy. |
format | Online Article Text |
id | pubmed-10563576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-105635762023-10-11 Role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among Indians Subramani, Murugan Anbarasan, Mudali Shanmugam, Deepalatha Muthumani, Lakshmi Narayanan Vasudevan, Pradeep Bioinformation Research Article Diabetic nephropathy/diabetic kidney disease (DKD) is one of the leading causes of renal failure. Early identification of the development or progression of diabetic nephropathy using appropriate screening and diagnostic tools is very important in order to provide timely and proper management. Inflammation plays a crucial role in development and progression of diabetic nephropathy. The aim of this study was to evaluate the relationship of inflammatory markers (neutrophil-to-lymphocyte ratio-NLR) as an early indicator to prevent the progression of diabetic kidney disease. A total of 158 patients with type 2 diabetes mellitus were distributed into three groups according urinary albumin-to-creatinine ratio. Levels of inflammatory markers neutrophil-to-lymphocyte ratio was recorded and compared among the three groups. Significant differences were detected between the groups in terms of neutrophil-to-lymphocyte ratio (p = 0.000).Characteristic curve analysis of inflammatory markers and microalbuminuria prediction demonstrated an area under curve (AUC) of 0.869 for neutrophil-to-lymphocyte ratio (p = 0.000). A NLR cut-off point of 2.2 has 72.3 % sensitivity and 78.1 % specificity, which suggested sufficient accuracy. Increased neutrophil-to-lymphocyte ratio was significantly correlated with diabetic nephropathy progression and increased neutrophil-to-lymphocyte ratio can be considered as an early indicator and a prognostic risk marker of diabetic nephropathy. Biomedical Informatics 2023-04-30 /pmc/articles/PMC10563576/ /pubmed/37822815 http://dx.doi.org/10.6026/97320630019375 Text en © 2023 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Research Article Subramani, Murugan Anbarasan, Mudali Shanmugam, Deepalatha Muthumani, Lakshmi Narayanan Vasudevan, Pradeep Role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among Indians |
title | Role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among Indians |
title_full | Role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among Indians |
title_fullStr | Role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among Indians |
title_full_unstemmed | Role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among Indians |
title_short | Role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among Indians |
title_sort | role of neutrophil-lymphocyte ratio as a prognostic marker for type 2 diabetic nephropathy among indians |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563576/ https://www.ncbi.nlm.nih.gov/pubmed/37822815 http://dx.doi.org/10.6026/97320630019375 |
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