Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice

OBJECTIVE: Nonautoimmune hyperthyroidism (NAH) is rare and occurs due to a constitutively activating thyroid stimulating hormone receptor (TSHR) mutation. In contrast to other thyroid nodules, no further evaluation for malignancy is recommended for hot thyroid nodules. In the first model for NAH in...

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Autores principales: Eszlinger, Markus, Stephenson, Alexandra, Mirhadi, Shideh, Patyra, Konrad, Moran, Michael F, Khalil, Moosa, Kero, Jukka, Paschke, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563634/
https://www.ncbi.nlm.nih.gov/pubmed/37655698
http://dx.doi.org/10.1530/ETJ-23-0049

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