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Evaluation of the therapeutic effect of Descurainia sophia (L.) Webb ex Prantl seed extract on hyperthyroidism: A double‐blind placebo‐controlled pilot clinical trial

The seeds of Descurainia sophia (L.) Webb ex Prantl contain goitrogenic glucosinolates, such as gluconapin (3‐butenyl glucosinolate). Because of the important role of iodine in the synthesis of thyroid hormones and the inhibitory activity of D. sophia on iodine uptake by the thyroid gland, this stud...

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Autores principales: Farzameh, Fatemeh, Azadbakht, Mohammad, Kashi, Zahra, Asgarirad, Hossein, Salehifar, Ebrahim, Mirzaee, Fatemeh, Davoodi, Ali, Amirkhanloo, Shervin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563688/
https://www.ncbi.nlm.nih.gov/pubmed/37823162
http://dx.doi.org/10.1002/fsn3.3522
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author Farzameh, Fatemeh
Azadbakht, Mohammad
Kashi, Zahra
Asgarirad, Hossein
Salehifar, Ebrahim
Mirzaee, Fatemeh
Davoodi, Ali
Amirkhanloo, Shervin
author_facet Farzameh, Fatemeh
Azadbakht, Mohammad
Kashi, Zahra
Asgarirad, Hossein
Salehifar, Ebrahim
Mirzaee, Fatemeh
Davoodi, Ali
Amirkhanloo, Shervin
author_sort Farzameh, Fatemeh
collection PubMed
description The seeds of Descurainia sophia (L.) Webb ex Prantl contain goitrogenic glucosinolates, such as gluconapin (3‐butenyl glucosinolate). Because of the important role of iodine in the synthesis of thyroid hormones and the inhibitory activity of D. sophia on iodine uptake by the thyroid gland, this study aimed to determine the effects of D. sophia syrup on clinical and biochemical variables of thyrotoxicosis in hyperthyroid patients. In this randomized, double‐blind trial, 10 newly diagnosed hyperthyroid female patients were randomly assigned to treatment with (1) methimazole (MMI) plus D. sophia capsules (350 mg/d) or (2) MMI plus placebo capsules. The primary outcomes were clinical and biochemical manifestations of hyperthyroidism after 60 days. Serum levels of FT3 and FT4 significantly decreased (5.9 ± 2.5 vs. 9.4 ± 5.9 and 29.1 ± 3.1 vs. 31.77 ± 3.7, respectively) and the serum thyroid‐stimulating hormone (TSH) concentration significantly increased in the D. sophia group contrasted to the placebo group (4.7 ± 0.1 vs. 0.05 ± 0.02). Significant improvement in the thyrotoxicosis clinical symptoms was reported in the D. sophia group contrasted to the placebo group (p < .05). D. sophia can suppress plasma levels of FT3 and FT4 and may be useful as adjunctive therapy for hyperthyroidism.
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spelling pubmed-105636882023-10-11 Evaluation of the therapeutic effect of Descurainia sophia (L.) Webb ex Prantl seed extract on hyperthyroidism: A double‐blind placebo‐controlled pilot clinical trial Farzameh, Fatemeh Azadbakht, Mohammad Kashi, Zahra Asgarirad, Hossein Salehifar, Ebrahim Mirzaee, Fatemeh Davoodi, Ali Amirkhanloo, Shervin Food Sci Nutr Original Articles The seeds of Descurainia sophia (L.) Webb ex Prantl contain goitrogenic glucosinolates, such as gluconapin (3‐butenyl glucosinolate). Because of the important role of iodine in the synthesis of thyroid hormones and the inhibitory activity of D. sophia on iodine uptake by the thyroid gland, this study aimed to determine the effects of D. sophia syrup on clinical and biochemical variables of thyrotoxicosis in hyperthyroid patients. In this randomized, double‐blind trial, 10 newly diagnosed hyperthyroid female patients were randomly assigned to treatment with (1) methimazole (MMI) plus D. sophia capsules (350 mg/d) or (2) MMI plus placebo capsules. The primary outcomes were clinical and biochemical manifestations of hyperthyroidism after 60 days. Serum levels of FT3 and FT4 significantly decreased (5.9 ± 2.5 vs. 9.4 ± 5.9 and 29.1 ± 3.1 vs. 31.77 ± 3.7, respectively) and the serum thyroid‐stimulating hormone (TSH) concentration significantly increased in the D. sophia group contrasted to the placebo group (4.7 ± 0.1 vs. 0.05 ± 0.02). Significant improvement in the thyrotoxicosis clinical symptoms was reported in the D. sophia group contrasted to the placebo group (p < .05). D. sophia can suppress plasma levels of FT3 and FT4 and may be useful as adjunctive therapy for hyperthyroidism. John Wiley and Sons Inc. 2023-07-04 /pmc/articles/PMC10563688/ /pubmed/37823162 http://dx.doi.org/10.1002/fsn3.3522 Text en © 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Farzameh, Fatemeh
Azadbakht, Mohammad
Kashi, Zahra
Asgarirad, Hossein
Salehifar, Ebrahim
Mirzaee, Fatemeh
Davoodi, Ali
Amirkhanloo, Shervin
Evaluation of the therapeutic effect of Descurainia sophia (L.) Webb ex Prantl seed extract on hyperthyroidism: A double‐blind placebo‐controlled pilot clinical trial
title Evaluation of the therapeutic effect of Descurainia sophia (L.) Webb ex Prantl seed extract on hyperthyroidism: A double‐blind placebo‐controlled pilot clinical trial
title_full Evaluation of the therapeutic effect of Descurainia sophia (L.) Webb ex Prantl seed extract on hyperthyroidism: A double‐blind placebo‐controlled pilot clinical trial
title_fullStr Evaluation of the therapeutic effect of Descurainia sophia (L.) Webb ex Prantl seed extract on hyperthyroidism: A double‐blind placebo‐controlled pilot clinical trial
title_full_unstemmed Evaluation of the therapeutic effect of Descurainia sophia (L.) Webb ex Prantl seed extract on hyperthyroidism: A double‐blind placebo‐controlled pilot clinical trial
title_short Evaluation of the therapeutic effect of Descurainia sophia (L.) Webb ex Prantl seed extract on hyperthyroidism: A double‐blind placebo‐controlled pilot clinical trial
title_sort evaluation of the therapeutic effect of descurainia sophia (l.) webb ex prantl seed extract on hyperthyroidism: a double‐blind placebo‐controlled pilot clinical trial
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563688/
https://www.ncbi.nlm.nih.gov/pubmed/37823162
http://dx.doi.org/10.1002/fsn3.3522
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