Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils

An acidic tumor microenvironment plays a critical role in tumor progression. However, understanding of metabolic reprogramming of tumors in response to acidic extracellular pH has remained elusive. Using comprehensive metabolomic analyses, we demonstrated that acidic extracellular pH (pH 6.8) leads...

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Detalles Bibliográficos
Autores principales: Kato, Miki, Maeda, Keisuke, Nakahara, Ryuichi, Hirose, Haruka, Kondo, Ayano, Aki, Sho, Sugaya, Maki, Hibino, Sana, Nishida, Miyuki, Hasegawa, Manami, Morita, Hinano, Ando, Ritsuko, Tsuchida, Rika, Yoshida, Minoru, Kodama, Tatsuhiko, Yanai, Hideyuki, Shimamura, Teppei, Osawa, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563787/
https://www.ncbi.nlm.nih.gov/pubmed/37822765
http://dx.doi.org/10.1093/pnasnexus/pgad306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563787/
https://www.ncbi.nlm.nih.gov/pubmed/37822765
http://dx.doi.org/10.1093/pnasnexus/pgad306

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