Cargando…

Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils

An acidic tumor microenvironment plays a critical role in tumor progression. However, understanding of metabolic reprogramming of tumors in response to acidic extracellular pH has remained elusive. Using comprehensive metabolomic analyses, we demonstrated that acidic extracellular pH (pH 6.8) leads...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kato, Miki, Maeda, Keisuke, Nakahara, Ryuichi, Hirose, Haruka, Kondo, Ayano, Aki, Sho, Sugaya, Maki, Hibino, Sana, Nishida, Miyuki, Hasegawa, Manami, Morita, Hinano, Ando, Ritsuko, Tsuchida, Rika, Yoshida, Minoru, Kodama, Tatsuhiko, Yanai, Hideyuki, Shimamura, Teppei, Osawa, Tsuyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Biological, Health, and Medical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563787/ https://www.ncbi.nlm.nih.gov/pubmed/37822765 http://dx.doi.org/10.1093/pnasnexus/pgad306

Ejemplares similares

Hypoxia activates SREBP2 through Golgi disassembly in bone marrow‐derived monocytes for enhanced tumor growth
por: Nakahara, Ryuichi, et al.
Publicado: (2023)

Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation
por: Kondo, Ayano, et al.
Publicado: (2017)

N1-acetylspermidine is a determinant of hair follicle stem cell fate
por: Allmeroth, Kira, et al.
Publicado: (2021)

N8‐Acetylspermidine: A Polyamine Biomarker in Ischemic Cardiomyopathy With Reduced Ejection Fraction
por: Nayak, Aditi, et al.
Publicado: (2020)

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement
por: Herp, Daniel, et al.
Publicado: (2022)

Protumor immunity and breast cancer development
por: Coussens, LM
Publicado: (2009)

Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation
por: Ito, Atene, et al.
Publicado: (2021)

High mammographic density in women is associated with protumor inflammation
por: Huo, Cecilia W., et al.
Publicado: (2018)

Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors
por: Barsac, Emilie, et al.
Publicado: (2021)

Tumor cell–derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8(+) T cell activation
por: Hibino, Sana, et al.
Publicado: (2023)

Metabolic adaptations of cancer in extreme tumor microenvironments
por: Nakahara, Ryuichi, et al.
Publicado: (2023)

Tumor-Associated Macrophages: Protumoral Macrophages in Inflammatory Tumor Microenvironment
por: Malekghasemi, Somaiyeh, et al.
Publicado: (2020)

An acid trip activates protumoral macrophages to promote hepatocellular carcinoma malignancy
por: Graham, Nicola, et al.
Publicado: (2022)

Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes
por: Komohara, Yoshihiro, et al.
Publicado: (2023)

Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma
por: Kurihara, M, et al.
Publicado: (2013)

Protumor Activities of the Immune Response: Insights in the Mechanisms of Immunological Shift, Oncotraining, and Oncopromotion
por: Chimal-Ramírez, G. K., et al.
Publicado: (2013)

Targeting the Tumor Microenvironment: The Protumor Effects of IL-17 Related to Cancer Type
por: Fabre, Joseph, et al.
Publicado: (2016)

Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution
por: Chung, Hwa Hwa, et al.
Publicado: (2017)

Enhanced lipid biosynthesis in human tumor-induced macrophages contributes to their protumoral characteristics
por: Rabold, Katrin, et al.
Publicado: (2020)

N‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages
por: Menga, Alessio, et al.
Publicado: (2021)

Basal Cell Carcinoma in Gorlin’s Patients: a Matter of Fibroblasts-Led Protumoral Microenvironment?
por: Gache, Yannick, et al.
Publicado: (2015)

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
por: Takahashi, Hideyuki, et al.
Publicado: (2016)

XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer
por: Zhao, Yahui, et al.
Publicado: (2021)

Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation
por: Kanki, Yasuharu, et al.
Publicado: (2017)

Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes
por: Chimal-Ramírez, G. Karina, et al.
Publicado: (2016)

Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids
por: Mola, Silvia, et al.
Publicado: (2021)

Current understanding of cancer-intrinsic PD-L1: regulation of expression and its protumoral activity
por: Yadollahi, Pedram, et al.
Publicado: (2021)

Nanotherapy delivery of c-myc inhibitor targets Protumor Macrophages and preserves Antitumor Macrophages in Breast Cancer
por: Esser, Alison K., et al.
Publicado: (2020)

Potential therapeutic targets in the tumor microenvironment of hepatocellular carcinoma: reversing the protumor effect of tumor-associated macrophages
por: Zhou, Jingyi, et al.
Publicado: (2021)

Targeting protumor factor chitinase-3-like-1 secreted by Rab37 vesicles for cancer immunotherapy
por: Yang, Pei-Shan, et al.
Publicado: (2022)

P044: PIM kinases support protumoral and immunosuppressive phenotype and functions of macrophages in classical Hodgkin Lymphoma
por: Szydłowski, Maciej, et al.
Publicado: (2022)

Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects
por: Jain, Saket, et al.
Publicado: (2023)

The Significance of SPP1 in Lung Cancers and Its Impact as a Marker for Protumor Tumor-Associated Macrophages
por: Matsubara, Eri, et al.
Publicado: (2023)

In Vivo Double Targeting of C26 Colon Carcinoma Cells and Microenvironmental Protumor Processes Using Liposomal Simvastatin
por: Luput, Lavinia, et al.
Publicado: (2018)

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages
por: Di Martile, Marta, et al.
Publicado: (2020)

CSF1R Inhibition Combined with GM-CSF Reprograms Macrophages and Disrupts Protumoral Interplays with AML Cells
por: Smirnova, Tatiana, et al.
Publicado: (2021)

Claudin-Low Breast Cancer Inflammatory Signatures Support Polarization of M1-Like Macrophages with Protumoral Activity
por: Suárez-Arriaga, Mayra Cecilia, et al.
Publicado: (2021)

Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma
por: Danlos, François-Xavier, et al.
Publicado: (2023)

Topological data analysis of protein structure and inter/intra-molecular interaction changes attributable to amino acid mutations
por: Koseki, Jun, et al.
Publicado: (2023)

Neutrophils with protumor potential could efficiently suppress tumor growth after cytokine priming and in presence of normal NK cells
por: Sun, Rui, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_hoj52ogcg9jabugb8247q9jj1k