Cargando…

Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress

The underlying biological mechanisms that contribute to the heterogeneity of major depressive disorder (MDD) presentation remain poorly understood, highlighting the need for a conceptual framework that can explain this variability and bridge the gap between animal models and clinical endpoints. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xiaolu, Eladawi, Mahmoud Ali, Ryan, William George, Fan, Xiaoming, Prevoznik, Stephen, Devale, Trupti, Ramnani, Barkha, Malathi, Krishnamurthy, Sibille, Etienne, Mccullumsmith, Robert, Tomoda, Toshifumi, Shukla, Rammohan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Biological, Health, and Medical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563789/ https://www.ncbi.nlm.nih.gov/pubmed/37822767 http://dx.doi.org/10.1093/pnasnexus/pgad299

Ejemplares similares

ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections
por: Ramnani, Barkha, et al.
Publicado: (2021)

Viral Hemorrhagic Septicemia Virus Activates Integrated Stress Response Pathway and Induces Stress Granules to Regulate Virus Replication
por: Ramnani, Barkha, et al.
Publicado: (2023)

Fluorescence-based cell-specific detection for laser-capture microdissection in human brain
por: Rocco, Brad R., et al.
Publicado: (2017)

The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders
por: O’Donovan, Sinead M., et al.
Publicado: (2017)

Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
por: Lin, Li-Chun, et al.
Publicado: (2013)

Dysregulation of Midbrain Dopamine System and the Pathophysiology of Schizophrenia
por: Sonnenschein, Susan F., et al.
Publicado: (2020)

Gene Enrichment Analysis of Astrocyte Subtypes in Psychiatric Disorders and Psychotropic Medication Datasets
por: Zhang, Xiaolu, et al.
Publicado: (2022)

S183. ABNORMALITIES IN SERINE/THREONINE SIGNALING NETWORKS IN SEVERE NEUROPSYCHIATRIC ILLNESS: DEVELOPMENT OF A PIPELINE TO EXPLORE ABNORMALITIES OF KINASE ACTIVITY AND IDENTIFY NOVEL TREATMENT STRATEGIES FOR SCHIZOPHRENIA
por: McCullumsmith, Robert, et al.
Publicado: (2020)

F201. KINASE NETWORK DYSREGULATION IN SCHIZOPHRENIA: IMPLICATIONS FOR NEW TREATMENT STRATEGIES
por: Bentea, Eduard, et al.
Publicado: (2018)

Dysregulated Metabolism in the Pathophysiology of Non-Allergic Obese Asthma
por: McCravy, Matthew, et al.
Publicado: (2021)

Advances in Unhealthy Nutrition and Circadian Dysregulation in Pathophysiology of NAFLD
por: Guo, Xin, et al.
Publicado: (2021)

Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis
por: Muniz-Santos, Renan, et al.
Publicado: (2023)

Altered Gene Synchrony Suggests a Combined Hormone-Mediated Dysregulated State in Major Depression
por: Gaiteri, Chris, et al.
Publicado: (2010)

Structural conservation of antibiotic interaction with ribosomes
por: Paternoga, Helge, et al.
Publicado: (2023)

Similarities and dissimilarities between psychiatric cluster disorders
por: Smail, Marissa A., et al.
Publicado: (2021)

Mechanisms of Synaptic Transmission Dysregulation in the Prefrontal Cortex: Pathophysiological Implications
por: Yan, Zhen, et al.
Publicado: (2022)

The dysregulation of leukemia inhibitory factor and its implications for endometriosis pathophysiology
por: Zutautas, Katherine B., et al.
Publicado: (2023)

Commentary: Effect of Yoga in Glaucoma Patients
por: Ramnani, Sakshi, et al.
Publicado: (2023)

Autophagy Dysregulation in Diabetic Kidney Disease: From Pathophysiology to Pharmacological Interventions
por: Gonzalez, Claudio D., et al.
Publicado: (2021)

Pleiotropic Roles of a Ribosomal Protein in Dictyostelium discoideum
por: Amarnath, Smita, et al.
Publicado: (2012)

Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases
por: Creeden, Justin F., et al.
Publicado: (2020)

Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy
por: Henkel, Nicholas D., et al.
Publicado: (2021)

Ribosomal Oxygenases are Structurally Conserved from Prokaryotes to Humans
por: Chowdhury, Rasheduzzaman, et al.
Publicado: (2014)

Folding pathway of an Ig domain is conserved on and off the ribosome
por: Tian, Pengfei, et al.
Publicado: (2018)

The conservation landscape of the human ribosomal RNA gene repeats
por: Agrawal, Saumya, et al.
Publicado: (2018)

The universally conserved nucleotides of the small subunit ribosomal RNAs
por: Noller, Harry F., et al.
Publicado: (2022)

A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism
por: Lin, Li-Chun, et al.
Publicado: (2011)

Fat Cell Size: Measurement Methods, Pathophysiological Origins, and Relationships With Metabolic Dysregulations
por: Ye, Run Zhou, et al.
Publicado: (2021)

Ribosome-associated Asc1/RACK1 is required for endonucleolytic cleavage induced by stalled ribosome at the 3′ end of nonstop mRNA
por: Ikeuchi, Ken, et al.
Publicado: (2016)

Conservation of physiological dysregulation signatures of aging across primates
por: Dansereau, Gabriel, et al.
Publicado: (2019)

The conserved GTPase HflX is a ribosome splitting factor that binds to the E-site of the bacterial ribosome
por: Coatham, Mackenzie L., et al.
Publicado: (2016)

Proteomics study reveals that the dysregulation of focal adhesion and ribosome contribute to early pregnancy loss
por: Xin, Lingli, et al.
Publicado: (2016)

Ubiquitination of stalled ribosome triggers ribosome-associated quality control
por: Matsuo, Yoshitaka, et al.
Publicado: (2017)

Insights into the origin of the nuclear localization signals in conserved ribosomal proteins
por: Melnikov, Sergey, et al.
Publicado: (2015)

Ribosomal DNA harbors an evolutionarily conserved clock of biological aging
por: Wang, Meng, et al.
Publicado: (2019)

VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems
por: Ravi, Barkha, et al.
Publicado: (2021)

Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia
por: Creeden, Justin F., et al.
Publicado: (2020)

Dysregulation of Ribosome Biogenesis and Translational Capacity Is Associated with Tumor Progression of Human Breast Cancer Cells
por: Belin, Stéphane, et al.
Publicado: (2009)

Dysregulation of ribosome-related genes in ankylosing spondylitis: a systems biology approach and experimental method
por: Lari, Arezou, et al.
Publicado: (2021)

Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3
por: Endo, Ryo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7pgugaod0es9q38udnfnre0fhf