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Validation of Igls Criteria for Islet Transplant Functional Status Using Person-Reported Outcome Measures in a Cross-Sectional Study

Associations between islet graft function and well-being in islet transplant recipients requiring exogenous insulin remain unclear. This cross-sectional analysis compared person-reported outcome measures in 15 adults with type 1 diabetes whose islet transplants were classified according to Igls crit...

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Autores principales: Bond, Zoe, Malik, Saffron, Bashir, Ayat, Stocker, Rachel, Buckingham, Jocelyn, Speight, Jane, Shaw, James A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563803/
https://www.ncbi.nlm.nih.gov/pubmed/37822448
http://dx.doi.org/10.3389/ti.2023.11659
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author Bond, Zoe
Malik, Saffron
Bashir, Ayat
Stocker, Rachel
Buckingham, Jocelyn
Speight, Jane
Shaw, James A. M.
author_facet Bond, Zoe
Malik, Saffron
Bashir, Ayat
Stocker, Rachel
Buckingham, Jocelyn
Speight, Jane
Shaw, James A. M.
author_sort Bond, Zoe
collection PubMed
description Associations between islet graft function and well-being in islet transplant recipients requiring exogenous insulin remain unclear. This cross-sectional analysis compared person-reported outcome measures in 15 adults with type 1 diabetes whose islet transplants were classified according to Igls criteria as “Good” (n = 5), “Marginal” (n = 4) and “Failed” (n = 6) graft function. At a mean of 6.2 years post-first islet transplant, 90% reduction in severe hypoglycaemia was maintained in all groups, with HbA1c (mean ± SD mmol/mol) 49 ± 4 in recipients with “Good” function; 56 ± 5 (“Marginal”); and 69 ± 25 (“Failed”). Self-reported impaired awareness of hypoglycaemia persisted in all groups but those with “Good” function were more likely to experience symptoms during hypoglycaemia. “Marginal” function was associated with greater fear of hypoglycaemia (HFS-II score: “Marginal”: 113 [95, 119]; “Failed”: 63 [42, 93] (p = 0.082); “Good”: 33 [29, 61]) and severe anxiety (GAD7: “Marginal”): 21 [17, 21]; “Failed”: 6 [6, 6] “Good”: 6 [3, 11]; (p = 0.079)), diabetes distress and low mood. Despite clear evidence of ongoing clinical benefit, Igls criteria ‘Marginal’ function is associated with sub-optimal well-being, including greater fear of hypoglycaemia and severe anxiety. This study provides person-reported validation that “Good” and “Marginal” graft function are differentiated by general and diabetes-specific subjective well-being, suggesting those with “Marginal” function may benefit from further intervention, including re-transplantation.
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spelling pubmed-105638032023-10-11 Validation of Igls Criteria for Islet Transplant Functional Status Using Person-Reported Outcome Measures in a Cross-Sectional Study Bond, Zoe Malik, Saffron Bashir, Ayat Stocker, Rachel Buckingham, Jocelyn Speight, Jane Shaw, James A. M. Transpl Int Health Archive Associations between islet graft function and well-being in islet transplant recipients requiring exogenous insulin remain unclear. This cross-sectional analysis compared person-reported outcome measures in 15 adults with type 1 diabetes whose islet transplants were classified according to Igls criteria as “Good” (n = 5), “Marginal” (n = 4) and “Failed” (n = 6) graft function. At a mean of 6.2 years post-first islet transplant, 90% reduction in severe hypoglycaemia was maintained in all groups, with HbA1c (mean ± SD mmol/mol) 49 ± 4 in recipients with “Good” function; 56 ± 5 (“Marginal”); and 69 ± 25 (“Failed”). Self-reported impaired awareness of hypoglycaemia persisted in all groups but those with “Good” function were more likely to experience symptoms during hypoglycaemia. “Marginal” function was associated with greater fear of hypoglycaemia (HFS-II score: “Marginal”: 113 [95, 119]; “Failed”: 63 [42, 93] (p = 0.082); “Good”: 33 [29, 61]) and severe anxiety (GAD7: “Marginal”): 21 [17, 21]; “Failed”: 6 [6, 6] “Good”: 6 [3, 11]; (p = 0.079)), diabetes distress and low mood. Despite clear evidence of ongoing clinical benefit, Igls criteria ‘Marginal’ function is associated with sub-optimal well-being, including greater fear of hypoglycaemia and severe anxiety. This study provides person-reported validation that “Good” and “Marginal” graft function are differentiated by general and diabetes-specific subjective well-being, suggesting those with “Marginal” function may benefit from further intervention, including re-transplantation. Frontiers Media S.A. 2023-09-26 /pmc/articles/PMC10563803/ /pubmed/37822448 http://dx.doi.org/10.3389/ti.2023.11659 Text en Copyright © 2023 Bond, Malik, Bashir, Stocker, Buckingham, Speight and Shaw. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Bond, Zoe
Malik, Saffron
Bashir, Ayat
Stocker, Rachel
Buckingham, Jocelyn
Speight, Jane
Shaw, James A. M.
Validation of Igls Criteria for Islet Transplant Functional Status Using Person-Reported Outcome Measures in a Cross-Sectional Study
title Validation of Igls Criteria for Islet Transplant Functional Status Using Person-Reported Outcome Measures in a Cross-Sectional Study
title_full Validation of Igls Criteria for Islet Transplant Functional Status Using Person-Reported Outcome Measures in a Cross-Sectional Study
title_fullStr Validation of Igls Criteria for Islet Transplant Functional Status Using Person-Reported Outcome Measures in a Cross-Sectional Study
title_full_unstemmed Validation of Igls Criteria for Islet Transplant Functional Status Using Person-Reported Outcome Measures in a Cross-Sectional Study
title_short Validation of Igls Criteria for Islet Transplant Functional Status Using Person-Reported Outcome Measures in a Cross-Sectional Study
title_sort validation of igls criteria for islet transplant functional status using person-reported outcome measures in a cross-sectional study
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563803/
https://www.ncbi.nlm.nih.gov/pubmed/37822448
http://dx.doi.org/10.3389/ti.2023.11659
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