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The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer

One of the most important factors involved in the response to oxidative stress (OS) is the nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of components such as antioxidative stress proteins and enzymes. Under normal conditions, Kelch-like ECH-associated protein 1...

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Autores principales: Xia, Lei, Ma, Wenbiao, Afrashteh, Ahmad, Sajadi, Mir Amirhossein, Fakheri, Hadi, Valilo, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Society of Medical Biochemistry and Laboratory Medicine 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564154/
https://www.ncbi.nlm.nih.gov/pubmed/37841775
http://dx.doi.org/10.11613/BM.2023.030504
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author Xia, Lei
Ma, Wenbiao
Afrashteh, Ahmad
Sajadi, Mir Amirhossein
Fakheri, Hadi
Valilo, Mohammad
author_facet Xia, Lei
Ma, Wenbiao
Afrashteh, Ahmad
Sajadi, Mir Amirhossein
Fakheri, Hadi
Valilo, Mohammad
author_sort Xia, Lei
collection PubMed
description One of the most important factors involved in the response to oxidative stress (OS) is the nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of components such as antioxidative stress proteins and enzymes. Under normal conditions, Kelch-like ECH-associated protein 1 (Keap1) keeps Nrf2 in the cytoplasm, thus preventing its translocation to the nucleus and inhibiting its role. It has been established that Nrf2 has a dual function; on the one hand, it promotes angiogenesis and cancer cell metastasis while causing resistance to drugs and chemotherapy. On the other hand, Nrf2 increases expression and proliferation of glutathione to protect cells against OS. p53 is a tumour suppressor that activates the apoptosis pathway in aging and cancer cells in addition to stimulating the glutaminolysis and antioxidant pathways. Cancer cells use the antioxidant ability of p53 against OS. Therefore, in the present study, we discussed function of Nrf2 and p53 in breast cancer (BC) cells to elucidate their role in protection or destruction of cancer cells as well as their drug resistance or antioxidant properties.
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spelling pubmed-105641542023-10-15 The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer Xia, Lei Ma, Wenbiao Afrashteh, Ahmad Sajadi, Mir Amirhossein Fakheri, Hadi Valilo, Mohammad Biochem Med (Zagreb) Reviews One of the most important factors involved in the response to oxidative stress (OS) is the nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of components such as antioxidative stress proteins and enzymes. Under normal conditions, Kelch-like ECH-associated protein 1 (Keap1) keeps Nrf2 in the cytoplasm, thus preventing its translocation to the nucleus and inhibiting its role. It has been established that Nrf2 has a dual function; on the one hand, it promotes angiogenesis and cancer cell metastasis while causing resistance to drugs and chemotherapy. On the other hand, Nrf2 increases expression and proliferation of glutathione to protect cells against OS. p53 is a tumour suppressor that activates the apoptosis pathway in aging and cancer cells in addition to stimulating the glutaminolysis and antioxidant pathways. Cancer cells use the antioxidant ability of p53 against OS. Therefore, in the present study, we discussed function of Nrf2 and p53 in breast cancer (BC) cells to elucidate their role in protection or destruction of cancer cells as well as their drug resistance or antioxidant properties. Croatian Society of Medical Biochemistry and Laboratory Medicine 2023-10-15 2023-10-15 /pmc/articles/PMC10564154/ /pubmed/37841775 http://dx.doi.org/10.11613/BM.2023.030504 Text en Croatian Society of Medical Biochemistry and Laboratory Medicine. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Xia, Lei
Ma, Wenbiao
Afrashteh, Ahmad
Sajadi, Mir Amirhossein
Fakheri, Hadi
Valilo, Mohammad
The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer
title The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer
title_full The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer
title_fullStr The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer
title_full_unstemmed The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer
title_short The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer
title_sort nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564154/
https://www.ncbi.nlm.nih.gov/pubmed/37841775
http://dx.doi.org/10.11613/BM.2023.030504
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