A Clinicopathological and Immunohistochemical Profile of Primary Extra Mammary Paget's Disease in Skin of Colour: A Case Series

Extramammary Paget's disease is an intraepithelial neoplasm, usually found in areas rich in apocrine gland concentration. The clinical features, histopathology, immunohistochemistry and management details of five patients (F = 3, M = 2) have been described here. While a well-defined persistent...

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Autores principales: Dhar, Subhra, Gupta, Divya, Chakraborty, Aditi, Malakar, Rajib, Dhar, Sandipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564206/
https://www.ncbi.nlm.nih.gov/pubmed/37822397
http://dx.doi.org/10.4103/ijd.ijd_99_23
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author Dhar, Subhra
Gupta, Divya
Chakraborty, Aditi
Malakar, Rajib
Dhar, Sandipan
author_facet Dhar, Subhra
Gupta, Divya
Chakraborty, Aditi
Malakar, Rajib
Dhar, Sandipan
author_sort Dhar, Subhra
collection PubMed
description Extramammary Paget's disease is an intraepithelial neoplasm, usually found in areas rich in apocrine gland concentration. The clinical features, histopathology, immunohistochemistry and management details of five patients (F = 3, M = 2) have been described here. While a well-defined persistent plaque with crusting and erosion was the most common presentation, hyperpigmentation, hypopigmentation and depigmentation were also observed in two patients. Characteristic Paget's cells with cytokeratin 7 and EMA positivity were seen on histopathology examination. Authors conclude that pigmentary alterations may be under-reported in extra mammary Paget's disease in the skin of colour.
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spelling pubmed-105642062023-10-11 A Clinicopathological and Immunohistochemical Profile of Primary Extra Mammary Paget's Disease in Skin of Colour: A Case Series Dhar, Subhra Gupta, Divya Chakraborty, Aditi Malakar, Rajib Dhar, Sandipan Indian J Dermatol Short Communication Extramammary Paget's disease is an intraepithelial neoplasm, usually found in areas rich in apocrine gland concentration. The clinical features, histopathology, immunohistochemistry and management details of five patients (F = 3, M = 2) have been described here. While a well-defined persistent plaque with crusting and erosion was the most common presentation, hyperpigmentation, hypopigmentation and depigmentation were also observed in two patients. Characteristic Paget's cells with cytokeratin 7 and EMA positivity were seen on histopathology examination. Authors conclude that pigmentary alterations may be under-reported in extra mammary Paget's disease in the skin of colour. Wolters Kluwer - Medknow 2023 /pmc/articles/PMC10564206/ /pubmed/37822397 http://dx.doi.org/10.4103/ijd.ijd_99_23 Text en Copyright: © 2023 Indian Journal of Dermatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Short Communication
Dhar, Subhra
Gupta, Divya
Chakraborty, Aditi
Malakar, Rajib
Dhar, Sandipan
A Clinicopathological and Immunohistochemical Profile of Primary Extra Mammary Paget's Disease in Skin of Colour: A Case Series
title A Clinicopathological and Immunohistochemical Profile of Primary Extra Mammary Paget's Disease in Skin of Colour: A Case Series
title_full A Clinicopathological and Immunohistochemical Profile of Primary Extra Mammary Paget's Disease in Skin of Colour: A Case Series
title_fullStr A Clinicopathological and Immunohistochemical Profile of Primary Extra Mammary Paget's Disease in Skin of Colour: A Case Series
title_full_unstemmed A Clinicopathological and Immunohistochemical Profile of Primary Extra Mammary Paget's Disease in Skin of Colour: A Case Series
title_short A Clinicopathological and Immunohistochemical Profile of Primary Extra Mammary Paget's Disease in Skin of Colour: A Case Series
title_sort clinicopathological and immunohistochemical profile of primary extra mammary paget's disease in skin of colour: a case series
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564206/
https://www.ncbi.nlm.nih.gov/pubmed/37822397
http://dx.doi.org/10.4103/ijd.ijd_99_23
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