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Respiratory virus surveillance in hospitalized children less than two-years of age in Kenema, Sierra Leone during the COVID-19 pandemic (October 2020- October 2021)

Globally, viral pathogens are the leading cause of acute respiratory infection in children under-five years. We aim to describe the epidemiology of viral respiratory pathogens in hospitalized children under-two years of age in Eastern Province of Sierra Leone, during the second year of the SARS-CoV-...

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Autores principales: Samuels, Robert J., Sumah, Ibrahim, Alhasan, Foday, McHenry, Rendie, Short, Laura, Chappell, James D., Haddadin, Zaid, Halasa, Natasha B., Valério, Inaê D., Amorim, Gustavo, Grant, Donald S., Schieffelin, John S., Moon, Troy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564235/
https://www.ncbi.nlm.nih.gov/pubmed/37816008
http://dx.doi.org/10.1371/journal.pone.0292652
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author Samuels, Robert J.
Sumah, Ibrahim
Alhasan, Foday
McHenry, Rendie
Short, Laura
Chappell, James D.
Haddadin, Zaid
Halasa, Natasha B.
Valério, Inaê D.
Amorim, Gustavo
Grant, Donald S.
Schieffelin, John S.
Moon, Troy D.
author_facet Samuels, Robert J.
Sumah, Ibrahim
Alhasan, Foday
McHenry, Rendie
Short, Laura
Chappell, James D.
Haddadin, Zaid
Halasa, Natasha B.
Valério, Inaê D.
Amorim, Gustavo
Grant, Donald S.
Schieffelin, John S.
Moon, Troy D.
author_sort Samuels, Robert J.
collection PubMed
description Globally, viral pathogens are the leading cause of acute respiratory infection in children under-five years. We aim to describe the epidemiology of viral respiratory pathogens in hospitalized children under-two years of age in Eastern Province of Sierra Leone, during the second year of the SARS-CoV-2 pandemic. We conducted a prospective study of children hospitalized with respiratory symptoms between October 2020 and October 2021. We collected demographic and clinical characteristics and calculated each participant´s respiratory symptom severity. Nose and throat swabs were collected at enrollment. Total nucleic acid was purified and tested for multiple respiratory viruses. Statistical analysis was performed using R version 4.2.0 software. 502 children less than two-years of age were enrolled. 376 (74.9%) had at least one respiratory virus detected. The most common viruses isolated were HRV/EV (28.2%), RSV (19.5%) and PIV (13.1%). Influenza and SARS-CoV-2 were identified in only 9.2% and 3.9% of children, respectively. Viral co-detection was common. Human metapneumovirus and RSV had more than two-fold higher odds of requiring O2 therapy while hospitalized. Viral pathogen prevalence was high (74.9%) in our study population. Despite this, 100% of children received antibiotics, underscoring a need to expand laboratory diagnostic capacity and to revisit clinical guidelines implementation in these children. Continuous surveillance and serologic studies among more diverse age groups, with greater geographic breadth, are needed in Sierra Leone to better characterize the long-term impact of COVID-19 on respiratory virus prevalence and to better characterize the seasonality of respiratory viruses in Sierra Leone.
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spelling pubmed-105642352023-10-11 Respiratory virus surveillance in hospitalized children less than two-years of age in Kenema, Sierra Leone during the COVID-19 pandemic (October 2020- October 2021) Samuels, Robert J. Sumah, Ibrahim Alhasan, Foday McHenry, Rendie Short, Laura Chappell, James D. Haddadin, Zaid Halasa, Natasha B. Valério, Inaê D. Amorim, Gustavo Grant, Donald S. Schieffelin, John S. Moon, Troy D. PLoS One Research Article Globally, viral pathogens are the leading cause of acute respiratory infection in children under-five years. We aim to describe the epidemiology of viral respiratory pathogens in hospitalized children under-two years of age in Eastern Province of Sierra Leone, during the second year of the SARS-CoV-2 pandemic. We conducted a prospective study of children hospitalized with respiratory symptoms between October 2020 and October 2021. We collected demographic and clinical characteristics and calculated each participant´s respiratory symptom severity. Nose and throat swabs were collected at enrollment. Total nucleic acid was purified and tested for multiple respiratory viruses. Statistical analysis was performed using R version 4.2.0 software. 502 children less than two-years of age were enrolled. 376 (74.9%) had at least one respiratory virus detected. The most common viruses isolated were HRV/EV (28.2%), RSV (19.5%) and PIV (13.1%). Influenza and SARS-CoV-2 were identified in only 9.2% and 3.9% of children, respectively. Viral co-detection was common. Human metapneumovirus and RSV had more than two-fold higher odds of requiring O2 therapy while hospitalized. Viral pathogen prevalence was high (74.9%) in our study population. Despite this, 100% of children received antibiotics, underscoring a need to expand laboratory diagnostic capacity and to revisit clinical guidelines implementation in these children. Continuous surveillance and serologic studies among more diverse age groups, with greater geographic breadth, are needed in Sierra Leone to better characterize the long-term impact of COVID-19 on respiratory virus prevalence and to better characterize the seasonality of respiratory viruses in Sierra Leone. Public Library of Science 2023-10-10 /pmc/articles/PMC10564235/ /pubmed/37816008 http://dx.doi.org/10.1371/journal.pone.0292652 Text en © 2023 Samuels et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Samuels, Robert J.
Sumah, Ibrahim
Alhasan, Foday
McHenry, Rendie
Short, Laura
Chappell, James D.
Haddadin, Zaid
Halasa, Natasha B.
Valério, Inaê D.
Amorim, Gustavo
Grant, Donald S.
Schieffelin, John S.
Moon, Troy D.
Respiratory virus surveillance in hospitalized children less than two-years of age in Kenema, Sierra Leone during the COVID-19 pandemic (October 2020- October 2021)
title Respiratory virus surveillance in hospitalized children less than two-years of age in Kenema, Sierra Leone during the COVID-19 pandemic (October 2020- October 2021)
title_full Respiratory virus surveillance in hospitalized children less than two-years of age in Kenema, Sierra Leone during the COVID-19 pandemic (October 2020- October 2021)
title_fullStr Respiratory virus surveillance in hospitalized children less than two-years of age in Kenema, Sierra Leone during the COVID-19 pandemic (October 2020- October 2021)
title_full_unstemmed Respiratory virus surveillance in hospitalized children less than two-years of age in Kenema, Sierra Leone during the COVID-19 pandemic (October 2020- October 2021)
title_short Respiratory virus surveillance in hospitalized children less than two-years of age in Kenema, Sierra Leone during the COVID-19 pandemic (October 2020- October 2021)
title_sort respiratory virus surveillance in hospitalized children less than two-years of age in kenema, sierra leone during the covid-19 pandemic (october 2020- october 2021)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564235/
https://www.ncbi.nlm.nih.gov/pubmed/37816008
http://dx.doi.org/10.1371/journal.pone.0292652
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