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Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians
Transmissible cancer cell lines are rare biological entities giving rise to diseases at the crossroads of cancer and parasitic diseases. These malignant cells have acquired the amazing capacity to spread from host to host. They have been described only in dogs, Tasmanian devils and marine bivalves....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564563/ https://www.ncbi.nlm.nih.gov/pubmed/37816387 http://dx.doi.org/10.1098/rsob.230259 |
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author | Burioli, E. A. V. Hammel, M. Vignal, E. Vidal-Dupiol, J. Mitta, G. Thomas, F. Bierne, N. Destoumieux-Garzón, D. Charrière, G. M. |
author_facet | Burioli, E. A. V. Hammel, M. Vignal, E. Vidal-Dupiol, J. Mitta, G. Thomas, F. Bierne, N. Destoumieux-Garzón, D. Charrière, G. M. |
author_sort | Burioli, E. A. V. |
collection | PubMed |
description | Transmissible cancer cell lines are rare biological entities giving rise to diseases at the crossroads of cancer and parasitic diseases. These malignant cells have acquired the amazing capacity to spread from host to host. They have been described only in dogs, Tasmanian devils and marine bivalves. The Mytilus trossulus bivalve transmissible neoplasia 2 (MtrBTN2) lineage has even acquired the capacity to spread inter-specifically between marine mussels of the Mytilus edulis complex worldwide. To identify the oncogenic processes underpinning the biology of these atypical cancers we performed transcriptomics of MtrBTN2 cells. Differential expression, enrichment, protein–protein interaction network, and targeted analyses were used. Overall, our results suggest the accumulation of multiple cancerous traits that may be linked to the long-term evolution of MtrBTN2. We also highlight that vertebrate and lophotrochozoan cancers could share a large panel of common drivers, which supports the hypothesis of an ancient origin of oncogenic processes in bilaterians. |
format | Online Article Text |
id | pubmed-10564563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-105645632023-10-11 Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians Burioli, E. A. V. Hammel, M. Vignal, E. Vidal-Dupiol, J. Mitta, G. Thomas, F. Bierne, N. Destoumieux-Garzón, D. Charrière, G. M. Open Biol Research Transmissible cancer cell lines are rare biological entities giving rise to diseases at the crossroads of cancer and parasitic diseases. These malignant cells have acquired the amazing capacity to spread from host to host. They have been described only in dogs, Tasmanian devils and marine bivalves. The Mytilus trossulus bivalve transmissible neoplasia 2 (MtrBTN2) lineage has even acquired the capacity to spread inter-specifically between marine mussels of the Mytilus edulis complex worldwide. To identify the oncogenic processes underpinning the biology of these atypical cancers we performed transcriptomics of MtrBTN2 cells. Differential expression, enrichment, protein–protein interaction network, and targeted analyses were used. Overall, our results suggest the accumulation of multiple cancerous traits that may be linked to the long-term evolution of MtrBTN2. We also highlight that vertebrate and lophotrochozoan cancers could share a large panel of common drivers, which supports the hypothesis of an ancient origin of oncogenic processes in bilaterians. The Royal Society 2023-10-11 /pmc/articles/PMC10564563/ /pubmed/37816387 http://dx.doi.org/10.1098/rsob.230259 Text en © 2023 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Research Burioli, E. A. V. Hammel, M. Vignal, E. Vidal-Dupiol, J. Mitta, G. Thomas, F. Bierne, N. Destoumieux-Garzón, D. Charrière, G. M. Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians |
title | Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians |
title_full | Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians |
title_fullStr | Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians |
title_full_unstemmed | Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians |
title_short | Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians |
title_sort | transcriptomics of mussel transmissible cancer mtrbtn2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564563/ https://www.ncbi.nlm.nih.gov/pubmed/37816387 http://dx.doi.org/10.1098/rsob.230259 |
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