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Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians

Transmissible cancer cell lines are rare biological entities giving rise to diseases at the crossroads of cancer and parasitic diseases. These malignant cells have acquired the amazing capacity to spread from host to host. They have been described only in dogs, Tasmanian devils and marine bivalves....

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Autores principales: Burioli, E. A. V., Hammel, M., Vignal, E., Vidal-Dupiol, J., Mitta, G., Thomas, F., Bierne, N., Destoumieux-Garzón, D., Charrière, G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564563/
https://www.ncbi.nlm.nih.gov/pubmed/37816387
http://dx.doi.org/10.1098/rsob.230259
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author Burioli, E. A. V.
Hammel, M.
Vignal, E.
Vidal-Dupiol, J.
Mitta, G.
Thomas, F.
Bierne, N.
Destoumieux-Garzón, D.
Charrière, G. M.
author_facet Burioli, E. A. V.
Hammel, M.
Vignal, E.
Vidal-Dupiol, J.
Mitta, G.
Thomas, F.
Bierne, N.
Destoumieux-Garzón, D.
Charrière, G. M.
author_sort Burioli, E. A. V.
collection PubMed
description Transmissible cancer cell lines are rare biological entities giving rise to diseases at the crossroads of cancer and parasitic diseases. These malignant cells have acquired the amazing capacity to spread from host to host. They have been described only in dogs, Tasmanian devils and marine bivalves. The Mytilus trossulus bivalve transmissible neoplasia 2 (MtrBTN2) lineage has even acquired the capacity to spread inter-specifically between marine mussels of the Mytilus edulis complex worldwide. To identify the oncogenic processes underpinning the biology of these atypical cancers we performed transcriptomics of MtrBTN2 cells. Differential expression, enrichment, protein–protein interaction network, and targeted analyses were used. Overall, our results suggest the accumulation of multiple cancerous traits that may be linked to the long-term evolution of MtrBTN2. We also highlight that vertebrate and lophotrochozoan cancers could share a large panel of common drivers, which supports the hypothesis of an ancient origin of oncogenic processes in bilaterians.
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spelling pubmed-105645632023-10-11 Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians Burioli, E. A. V. Hammel, M. Vignal, E. Vidal-Dupiol, J. Mitta, G. Thomas, F. Bierne, N. Destoumieux-Garzón, D. Charrière, G. M. Open Biol Research Transmissible cancer cell lines are rare biological entities giving rise to diseases at the crossroads of cancer and parasitic diseases. These malignant cells have acquired the amazing capacity to spread from host to host. They have been described only in dogs, Tasmanian devils and marine bivalves. The Mytilus trossulus bivalve transmissible neoplasia 2 (MtrBTN2) lineage has even acquired the capacity to spread inter-specifically between marine mussels of the Mytilus edulis complex worldwide. To identify the oncogenic processes underpinning the biology of these atypical cancers we performed transcriptomics of MtrBTN2 cells. Differential expression, enrichment, protein–protein interaction network, and targeted analyses were used. Overall, our results suggest the accumulation of multiple cancerous traits that may be linked to the long-term evolution of MtrBTN2. We also highlight that vertebrate and lophotrochozoan cancers could share a large panel of common drivers, which supports the hypothesis of an ancient origin of oncogenic processes in bilaterians. The Royal Society 2023-10-11 /pmc/articles/PMC10564563/ /pubmed/37816387 http://dx.doi.org/10.1098/rsob.230259 Text en © 2023 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Research
Burioli, E. A. V.
Hammel, M.
Vignal, E.
Vidal-Dupiol, J.
Mitta, G.
Thomas, F.
Bierne, N.
Destoumieux-Garzón, D.
Charrière, G. M.
Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians
title Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians
title_full Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians
title_fullStr Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians
title_full_unstemmed Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians
title_short Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians
title_sort transcriptomics of mussel transmissible cancer mtrbtn2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564563/
https://www.ncbi.nlm.nih.gov/pubmed/37816387
http://dx.doi.org/10.1098/rsob.230259
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