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Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review
A category of diseases known as cancer includes abnormal cell development and the ability to infiltrate or spread to other regions of the body, making them a major cause of mortality worldwide. Chemotherapy, radiation, the use of cytotoxic medicines, and surgery are the mainstays of cancer treatment...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Cancer Prevention
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564632/ https://www.ncbi.nlm.nih.gov/pubmed/37830114 http://dx.doi.org/10.15430/JCP.2023.28.3.77 |
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author | Yasmin, Raihana Gogoi, Sangeeta Bora, Jumi Chakraborty, Arijit Dey, Susmita Ghaziri, Ghazal Bhattacharjee, Surajit Singh, Laishram Hemchandra |
author_facet | Yasmin, Raihana Gogoi, Sangeeta Bora, Jumi Chakraborty, Arijit Dey, Susmita Ghaziri, Ghazal Bhattacharjee, Surajit Singh, Laishram Hemchandra |
author_sort | Yasmin, Raihana |
collection | PubMed |
description | A category of diseases known as cancer includes abnormal cell development and the ability to infiltrate or spread to other regions of the body, making them a major cause of mortality worldwide. Chemotherapy, radiation, the use of cytotoxic medicines, and surgery are the mainstays of cancer treatment today. Plants or products produced from them hold promise as a source of anti-cancer medications that have fewer adverse effects. Due to the presence of numerous phytochemicals that have been isolated from various parts of the Hibiscus sabdariffa (HS) plant, including anthocyanin, flavonoids, saponins, tannins, polyphenols, organic acids, caffeic acids, citric acids, protocatechuic acid, and others, extracts of this plant have been reported to have anti-cancer effects. These compounds have been shown to reduce cancer cell proliferation, induce apoptosis, and cause cell cycle arrest. They also increase the expression levels of the cell cycle inhibitors (p53, p21, and p27) and the pro-apoptotic proteins (BAD, Bax, caspase 3, caspase 7, caspase 8, and caspase 9). This review highlights various intracellular signalling pathways involved in cancer preventive potential of HS. |
format | Online Article Text |
id | pubmed-10564632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Society of Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-105646322023-10-12 Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review Yasmin, Raihana Gogoi, Sangeeta Bora, Jumi Chakraborty, Arijit Dey, Susmita Ghaziri, Ghazal Bhattacharjee, Surajit Singh, Laishram Hemchandra J Cancer Prev Review A category of diseases known as cancer includes abnormal cell development and the ability to infiltrate or spread to other regions of the body, making them a major cause of mortality worldwide. Chemotherapy, radiation, the use of cytotoxic medicines, and surgery are the mainstays of cancer treatment today. Plants or products produced from them hold promise as a source of anti-cancer medications that have fewer adverse effects. Due to the presence of numerous phytochemicals that have been isolated from various parts of the Hibiscus sabdariffa (HS) plant, including anthocyanin, flavonoids, saponins, tannins, polyphenols, organic acids, caffeic acids, citric acids, protocatechuic acid, and others, extracts of this plant have been reported to have anti-cancer effects. These compounds have been shown to reduce cancer cell proliferation, induce apoptosis, and cause cell cycle arrest. They also increase the expression levels of the cell cycle inhibitors (p53, p21, and p27) and the pro-apoptotic proteins (BAD, Bax, caspase 3, caspase 7, caspase 8, and caspase 9). This review highlights various intracellular signalling pathways involved in cancer preventive potential of HS. Korean Society of Cancer Prevention 2023-09-30 2023-09-30 /pmc/articles/PMC10564632/ /pubmed/37830114 http://dx.doi.org/10.15430/JCP.2023.28.3.77 Text en Copyright © 2023 Korean Society of Cancer Prevention https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Yasmin, Raihana Gogoi, Sangeeta Bora, Jumi Chakraborty, Arijit Dey, Susmita Ghaziri, Ghazal Bhattacharjee, Surajit Singh, Laishram Hemchandra Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review |
title | Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review |
title_full | Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review |
title_fullStr | Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review |
title_full_unstemmed | Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review |
title_short | Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review |
title_sort | novel insight into the cellular and molecular signalling pathways on cancer preventing effects of hibiscus sabdariffa: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564632/ https://www.ncbi.nlm.nih.gov/pubmed/37830114 http://dx.doi.org/10.15430/JCP.2023.28.3.77 |
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