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Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels
KEY MESSAGE: An original GWAS model integrating the ancestry of alleles was proposed and allowed the detection of background specific additive and dominance QTLs involved in heterotic group complementarity and hybrid performance. ABSTRACT: Maize genetic diversity is structured into genetic groups se...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564676/ https://www.ncbi.nlm.nih.gov/pubmed/37816986 http://dx.doi.org/10.1007/s00122-023-04431-w |
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author | Beugnot, Aurélien Mary-Huard, Tristan Bauland, Cyril Combes, Valerie Madur, Delphine Lagardère, Bernard Palaffre, Carine Charcosset, Alain Moreau, Laurence Fievet, Julie B. |
author_facet | Beugnot, Aurélien Mary-Huard, Tristan Bauland, Cyril Combes, Valerie Madur, Delphine Lagardère, Bernard Palaffre, Carine Charcosset, Alain Moreau, Laurence Fievet, Julie B. |
author_sort | Beugnot, Aurélien |
collection | PubMed |
description | KEY MESSAGE: An original GWAS model integrating the ancestry of alleles was proposed and allowed the detection of background specific additive and dominance QTLs involved in heterotic group complementarity and hybrid performance. ABSTRACT: Maize genetic diversity is structured into genetic groups selected and improved relative to each other. This process increases group complementarity and differentiation over time and ensures that the hybrids produced from inter-group crosses exhibit high performances and heterosis. To identify loci involved in hybrid performance and heterotic group complementarity, we introduced an original association study model that disentangles allelic effects from the heterotic group origin of the alleles and compared it with a conventional additive/dominance model. This new model was applied on a factorial between Dent and Flint lines and a diallel between Dent-Flint admixed lines with two different layers of analysis: within each environment and in a multiple-environment context. We identified several strong additive QTLs for all traits, including some well-known additive QTLs for flowering time (in the region of Vgt1/2 on chromosome 8). Yield trait displayed significant non-additive effects in the diallel panel. Most of the detected Yield QTLs exhibited overdominance or, more likely, pseudo-overdominance effects. Apparent overdominance at these QTLs contributed to a part of the genetic group complementarity. The comparison between environments revealed a higher stability of additive QTL effects than non-additive ones. Several QTLs showed variations of effects according to the local heterotic group origin. We also revealed large chromosomic regions that display genetic group origin effects. Altogether, our results illustrate how admixed panels combined with dedicated GWAS modeling allow the identification of new QTLs that could not be revealed by a classical hybrid panel analyzed with traditional modeling. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00122-023-04431-w. |
format | Online Article Text |
id | pubmed-10564676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-105646762023-10-12 Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels Beugnot, Aurélien Mary-Huard, Tristan Bauland, Cyril Combes, Valerie Madur, Delphine Lagardère, Bernard Palaffre, Carine Charcosset, Alain Moreau, Laurence Fievet, Julie B. Theor Appl Genet Original Article KEY MESSAGE: An original GWAS model integrating the ancestry of alleles was proposed and allowed the detection of background specific additive and dominance QTLs involved in heterotic group complementarity and hybrid performance. ABSTRACT: Maize genetic diversity is structured into genetic groups selected and improved relative to each other. This process increases group complementarity and differentiation over time and ensures that the hybrids produced from inter-group crosses exhibit high performances and heterosis. To identify loci involved in hybrid performance and heterotic group complementarity, we introduced an original association study model that disentangles allelic effects from the heterotic group origin of the alleles and compared it with a conventional additive/dominance model. This new model was applied on a factorial between Dent and Flint lines and a diallel between Dent-Flint admixed lines with two different layers of analysis: within each environment and in a multiple-environment context. We identified several strong additive QTLs for all traits, including some well-known additive QTLs for flowering time (in the region of Vgt1/2 on chromosome 8). Yield trait displayed significant non-additive effects in the diallel panel. Most of the detected Yield QTLs exhibited overdominance or, more likely, pseudo-overdominance effects. Apparent overdominance at these QTLs contributed to a part of the genetic group complementarity. The comparison between environments revealed a higher stability of additive QTL effects than non-additive ones. Several QTLs showed variations of effects according to the local heterotic group origin. We also revealed large chromosomic regions that display genetic group origin effects. Altogether, our results illustrate how admixed panels combined with dedicated GWAS modeling allow the identification of new QTLs that could not be revealed by a classical hybrid panel analyzed with traditional modeling. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00122-023-04431-w. Springer Berlin Heidelberg 2023-10-10 2023 /pmc/articles/PMC10564676/ /pubmed/37816986 http://dx.doi.org/10.1007/s00122-023-04431-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Beugnot, Aurélien Mary-Huard, Tristan Bauland, Cyril Combes, Valerie Madur, Delphine Lagardère, Bernard Palaffre, Carine Charcosset, Alain Moreau, Laurence Fievet, Julie B. Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels |
title | Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels |
title_full | Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels |
title_fullStr | Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels |
title_full_unstemmed | Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels |
title_short | Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels |
title_sort | identifying qtls involved in hybrid performance and heterotic group complementarity: new gwas models applied to factorial and admixed diallel maize hybrid panels |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564676/ https://www.ncbi.nlm.nih.gov/pubmed/37816986 http://dx.doi.org/10.1007/s00122-023-04431-w |
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