Cargando…

Integrated single-cell and spatial transcriptomics reveals heterogeneity of fibroblast and pivotal genes in psoriasis

Psoriasis, which is one of the most common skin diseases, involves an array of complex immune constituents including T cells, dendritic cells and monocytes. Particularly, the cytokine IL17A, primarily generated by TH17 cells, assumes a crucial function in the etiology of psoriasis. In this study, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Cong-cong, Song, Tian-cong, Qi, Rui-qun, Gao, Xing-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564713/ https://www.ncbi.nlm.nih.gov/pubmed/37816883 http://dx.doi.org/10.1038/s41598-023-44346-6

Ejemplares similares

Integrated single‐cell and spatial transcriptomic profiling reveals higher intratumour heterogeneity and epithelial–fibroblast interactions in recurrent bladder cancer
por: Shi, Zhen‐Duo, et al.
Publicado: (2023)

Integrated spatial transcriptome and metabolism study reveals metabolic heterogeneity in human injured brain
por: Zheng, Ping, et al.
Publicado: (2023)

Single-cell transcriptome reveals cellular heterogeneity and lineage-specific regulatory changes of fibroblasts in post-traumatic urethral stricture
por: Li, Kuiqing, et al.
Publicado: (2023)

Integration of single-cell RNA sequencing and spatial transcriptomics to reveal the glioblastoma heterogeneity
por: Perdyan, Adrian, et al.
Publicado: (2023)

Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer
por: Wang, Fei, et al.
Publicado: (2023)

Deubiquitinases as pivotal regulators of T cell functions
por: Yang, Xiao-Dong, et al.
Publicado: (2018)

Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis
por: Zhang, Chuan, et al.
Publicado: (2021)

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer
por: Sebastian, Aimy, et al.
Publicado: (2020)

Integration of single-cell RNA sequencing and bulk RNA transcriptome sequencing reveals a heterogeneous immune landscape and pivotal cell subpopulations associated with colorectal cancer prognosis
por: Zhang, Qian, et al.
Publicado: (2023)

Spatial transcriptomic and single-nucleus analysis reveals heterogeneity in a gigantic single-celled syncytium
por: Gerber, Tobias, et al.
Publicado: (2022)

Integrated bioinformatic analysis of differentially expressed genes and signaling pathways in plaque psoriasis
por: Zhang, Yu-Jing, et al.
Publicado: (2019)

Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis
por: Ma, Feiyang, et al.
Publicado: (2023)

Integration analysis of single-cell and spatial transcriptomics reveal the cellular heterogeneity landscape in glioblastoma and establish a polygenic risk model
por: Liu, Yaxuan, et al.
Publicado: (2023)

Spatial transcriptomics reveals the heterogeneity and FGG+CRP+ inflammatory cancer-associated fibroblasts replace islets in pancreatic ductal adenocarcinoma
por: Ren, Zhangyong, et al.
Publicado: (2023)

Single-Cell Transcriptome Integration Analysis Reveals the Correlation Between Mesenchymal Stromal Cells and Fibroblasts
por: Fan, Chuiqin, et al.
Publicado: (2022)

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity
por: Joost, Simon, et al.
Publicado: (2016)

Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathy
por: Fu, Weili, et al.
Publicado: (2023)

Defining Patient-Level Molecular Heterogeneity in Psoriasis Vulgaris Based on Single-Cell Transcriptomics
por: Liu, Yale, et al.
Publicado: (2022)

Prokineticin 2 Plays a Pivotal Role in Psoriasis
por: He, Xiaoqin, et al.
Publicado: (2016)

Single‐cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts
por: Phan, Quan M., et al.
Publicado: (2020)

Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects
por: Jain, Saket, et al.
Publicado: (2023)

Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis
por: Xu, Kun, et al.
Publicado: (2021)

Gamma Delta T Cells and Their Pathogenic Role in Psoriasis
por: Qi, Cong, et al.
Publicado: (2021)

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
por: Berglund, Emelie, et al.
Publicado: (2018)

Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis
por: Peng, Liao, et al.
Publicado: (2022)

Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics
por: Qin, Pengfei, et al.
Publicado: (2023)

Meaningful Integration of Data from Heterogeneous Health Services and Home Environment Based on Ontology †
por: Peng, Cong, et al.
Publicado: (2019)

Dysregulation of Connexin Expression Plays a Pivotal Role in Psoriasis
por: O’Shaughnessy, Erin M., et al.
Publicado: (2021)

Transcriptomic analysis reveals genetic factors regulating early steroid-induced osteonecrosis of the femoral head
por: Tian, Cong, et al.
Publicado: (2022)

The role of fatty acid desaturase 2 in multiple tumor types revealed by bulk and single-cell transcriptomes
por: Chen, Enli, et al.
Publicado: (2023)

Single-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancer
por: Tian, Yanhua, et al.
Publicado: (2022)

Comprehensive Integrated Single-Cell Whole Transcriptome Analysis Revealed the p-EMT Tumor Cells—CAFs Communication in Oral Squamous Cell Carcinoma
por: Huynh, Nam Cong-Nhat, et al.
Publicado: (2022)

Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis
por: Chen, Chao, et al.
Publicado: (2021)

Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment
por: Dinh, Huy Q., et al.
Publicado: (2021)

Detecting transcriptomic structural variants in heterogeneous contexts via the Multiple Compatible Arrangements Problem
por: Qiu, Yutong, et al.
Publicado: (2020)

Transcriptomics Integrated With Metabolomics Reveal the Effects of Ultraviolet-B Radiation on Flavonoid Biosynthesis in Antarctic Moss
por: Liu, Shenghao, et al.
Publicado: (2021)

Integrated transcriptome and metabolome analyses reveal the adaptation of Antarctic moss Pohlia nutans to drought stress
por: Fang, Shuo, et al.
Publicado: (2022)

Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney
por: Wu, Hongwei, et al.
Publicado: (2022)

Spatial Transcriptomics for Tumor Heterogeneity Analysis
por: Li, Qiongyu, et al.
Publicado: (2022)

Integrated spatial multiomics reveals fibroblast fate during tissue repair
por: Foster, Deshka S., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0pd82sgsui3jqbv9tbf4r28vn5