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Unaltered hepatic wound healing response in male rats with ancestral liver injury
The possibility that ancestral environmental exposure could result in adaptive inherited effects in mammals has been long debated. Numerous rodent models of transgenerational responses to various environmental factors have been published but due to technical, operational and resource burden, most st...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564731/ https://www.ncbi.nlm.nih.gov/pubmed/37816736 http://dx.doi.org/10.1038/s41467-023-41998-w |
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author | Beil, Johanna Perner, Juliane Pfaller, Lena Gérard, Marie-Apolline Piaia, Alessandro Doelemeyer, Arno Wasserkrug Naor, Adi Martin, Lori Piequet, Aline Dubost, Valérie Chibout, Salah-Dine Moggs, Jonathan Terranova, Rémi |
author_facet | Beil, Johanna Perner, Juliane Pfaller, Lena Gérard, Marie-Apolline Piaia, Alessandro Doelemeyer, Arno Wasserkrug Naor, Adi Martin, Lori Piequet, Aline Dubost, Valérie Chibout, Salah-Dine Moggs, Jonathan Terranova, Rémi |
author_sort | Beil, Johanna |
collection | PubMed |
description | The possibility that ancestral environmental exposure could result in adaptive inherited effects in mammals has been long debated. Numerous rodent models of transgenerational responses to various environmental factors have been published but due to technical, operational and resource burden, most still await independent confirmation. A previous study reported multigenerational epigenetic adaptation of the hepatic wound healing response upon exposure to the hepatotoxicant carbon tetrachloride (CCl(4)) in male rats. Here, we comprehensively investigate the transgenerational effects by repeating the original CCl(4) multigenerational study with increased power, pedigree tracing, F2 dose-response and suitable randomization schemes. Detailed pathology evaluations do not support adaptive phenotypic suppression of the hepatic wound healing response or a greater fitness of F2 animals with ancestral liver injury exposure. However, transcriptomic analyses identified genes whose expression correlates with ancestral liver injury, although the biological relevance of this apparent transgenerational transmission at the molecular level remains to be determined. This work overall highlights the need for independent evaluation of transgenerational epigenetic inheritance paradigms in mammals. |
format | Online Article Text |
id | pubmed-10564731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105647312023-10-12 Unaltered hepatic wound healing response in male rats with ancestral liver injury Beil, Johanna Perner, Juliane Pfaller, Lena Gérard, Marie-Apolline Piaia, Alessandro Doelemeyer, Arno Wasserkrug Naor, Adi Martin, Lori Piequet, Aline Dubost, Valérie Chibout, Salah-Dine Moggs, Jonathan Terranova, Rémi Nat Commun Article The possibility that ancestral environmental exposure could result in adaptive inherited effects in mammals has been long debated. Numerous rodent models of transgenerational responses to various environmental factors have been published but due to technical, operational and resource burden, most still await independent confirmation. A previous study reported multigenerational epigenetic adaptation of the hepatic wound healing response upon exposure to the hepatotoxicant carbon tetrachloride (CCl(4)) in male rats. Here, we comprehensively investigate the transgenerational effects by repeating the original CCl(4) multigenerational study with increased power, pedigree tracing, F2 dose-response and suitable randomization schemes. Detailed pathology evaluations do not support adaptive phenotypic suppression of the hepatic wound healing response or a greater fitness of F2 animals with ancestral liver injury exposure. However, transcriptomic analyses identified genes whose expression correlates with ancestral liver injury, although the biological relevance of this apparent transgenerational transmission at the molecular level remains to be determined. This work overall highlights the need for independent evaluation of transgenerational epigenetic inheritance paradigms in mammals. Nature Publishing Group UK 2023-10-10 /pmc/articles/PMC10564731/ /pubmed/37816736 http://dx.doi.org/10.1038/s41467-023-41998-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Beil, Johanna Perner, Juliane Pfaller, Lena Gérard, Marie-Apolline Piaia, Alessandro Doelemeyer, Arno Wasserkrug Naor, Adi Martin, Lori Piequet, Aline Dubost, Valérie Chibout, Salah-Dine Moggs, Jonathan Terranova, Rémi Unaltered hepatic wound healing response in male rats with ancestral liver injury |
title | Unaltered hepatic wound healing response in male rats with ancestral liver injury |
title_full | Unaltered hepatic wound healing response in male rats with ancestral liver injury |
title_fullStr | Unaltered hepatic wound healing response in male rats with ancestral liver injury |
title_full_unstemmed | Unaltered hepatic wound healing response in male rats with ancestral liver injury |
title_short | Unaltered hepatic wound healing response in male rats with ancestral liver injury |
title_sort | unaltered hepatic wound healing response in male rats with ancestral liver injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564731/ https://www.ncbi.nlm.nih.gov/pubmed/37816736 http://dx.doi.org/10.1038/s41467-023-41998-w |
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