Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice

Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly affects mitochondrial oxidative phosphorylation (OXPHOS) by regulating mitochondrial transcription factors TFAM and PGC1α, and it...

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Detalles Bibliográficos
Autores principales: Venit, Tomas, Sapkota, Oscar, Abdrabou, Wael Said, Loganathan, Palanikumar, Pasricha, Renu, Mahmood, Syed Raza, El Said, Nadine Hosny, Sherif, Shimaa, Thomas, Sneha, Abdelrazig, Salah, Amin, Shady, Bedognetti, Davide, Idaghdour, Youssef, Magzoub, Mazin, Percipalle, Piergiorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564744/
https://www.ncbi.nlm.nih.gov/pubmed/37816864
http://dx.doi.org/10.1038/s41467-023-42093-w

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