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A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes

Global eradication of poliovirus remains elusive, and it is critical to develop next generation vaccines and antivirals. In support of this goal, we map the epitope of human monoclonal antibody 9H2 which is able to neutralize the three serotypes of poliovirus. Using cryo-EM we solve the near-atomic...

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Detalles Bibliográficos
Autores principales:	Charnesky, Andrew J., Faust, Julia E., Lee, Hyunwook, Puligedda, Rama Devudu, Goetschius, Daniel J., DiNunno, Nadia M., Thapa, Vaskar, Bator, Carol M., Cho, Sung Hyun (Joseph), Wahid, Rahnuma, Mahmood, Kutub, Dessain, Scott, Chumakov, Konstantin M., Rosenfeld, Amy, Hafenstein, Susan L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564760/ https://www.ncbi.nlm.nih.gov/pubmed/37816742 http://dx.doi.org/10.1038/s41467-023-41052-9

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