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The medial septum controls hippocampal supra-theta oscillations

Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) a...

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Autores principales: Király, Bálint, Domonkos, Andor, Jelitai, Márta, Lopes-dos-Santos, Vítor, Martínez-Bellver, Sergio, Kocsis, Barnabás, Schlingloff, Dániel, Joshi, Abhilasha, Salib, Minas, Fiáth, Richárd, Barthó, Péter, Ulbert, István, Freund, Tamás F., Viney, Tim J., Dupret, David, Varga, Viktor, Hangya, Balázs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564782/
https://www.ncbi.nlm.nih.gov/pubmed/37816713
http://dx.doi.org/10.1038/s41467-023-41746-0
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author Király, Bálint
Domonkos, Andor
Jelitai, Márta
Lopes-dos-Santos, Vítor
Martínez-Bellver, Sergio
Kocsis, Barnabás
Schlingloff, Dániel
Joshi, Abhilasha
Salib, Minas
Fiáth, Richárd
Barthó, Péter
Ulbert, István
Freund, Tamás F.
Viney, Tim J.
Dupret, David
Varga, Viktor
Hangya, Balázs
author_facet Király, Bálint
Domonkos, Andor
Jelitai, Márta
Lopes-dos-Santos, Vítor
Martínez-Bellver, Sergio
Kocsis, Barnabás
Schlingloff, Dániel
Joshi, Abhilasha
Salib, Minas
Fiáth, Richárd
Barthó, Péter
Ulbert, István
Freund, Tamás F.
Viney, Tim J.
Dupret, David
Varga, Viktor
Hangya, Balázs
author_sort Király, Bálint
collection PubMed
description Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval.
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spelling pubmed-105647822023-10-12 The medial septum controls hippocampal supra-theta oscillations Király, Bálint Domonkos, Andor Jelitai, Márta Lopes-dos-Santos, Vítor Martínez-Bellver, Sergio Kocsis, Barnabás Schlingloff, Dániel Joshi, Abhilasha Salib, Minas Fiáth, Richárd Barthó, Péter Ulbert, István Freund, Tamás F. Viney, Tim J. Dupret, David Varga, Viktor Hangya, Balázs Nat Commun Article Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval. Nature Publishing Group UK 2023-10-10 /pmc/articles/PMC10564782/ /pubmed/37816713 http://dx.doi.org/10.1038/s41467-023-41746-0 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Király, Bálint
Domonkos, Andor
Jelitai, Márta
Lopes-dos-Santos, Vítor
Martínez-Bellver, Sergio
Kocsis, Barnabás
Schlingloff, Dániel
Joshi, Abhilasha
Salib, Minas
Fiáth, Richárd
Barthó, Péter
Ulbert, István
Freund, Tamás F.
Viney, Tim J.
Dupret, David
Varga, Viktor
Hangya, Balázs
The medial septum controls hippocampal supra-theta oscillations
title The medial septum controls hippocampal supra-theta oscillations
title_full The medial septum controls hippocampal supra-theta oscillations
title_fullStr The medial septum controls hippocampal supra-theta oscillations
title_full_unstemmed The medial septum controls hippocampal supra-theta oscillations
title_short The medial septum controls hippocampal supra-theta oscillations
title_sort medial septum controls hippocampal supra-theta oscillations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564782/
https://www.ncbi.nlm.nih.gov/pubmed/37816713
http://dx.doi.org/10.1038/s41467-023-41746-0
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