Transcriptional mutagenesis of α-synuclein caused by DNA oxidation in Parkinson’s disease pathogenesis

Oxidative stress plays an essential role in the development of Parkinson’s disease (PD). 8-oxo-7,8-dihydroguanine (8-oxodG, oxidized guanine) is the most abundant oxidative stress-mediated DNA lesion. However, its contributing role in underlying PD pathogenesis remains unknown. In this study, we hyp...

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Detalles Bibliográficos
Autores principales: Basu, Sambuddha, Song, Minkyung, Adams, Levi, Jeong, Inhye, Je, Goun, Guhathakurta, Subhrangshu, Jiang, Jennifer, Boparai, Nikpreet, Dai, Wei, Cardozo-Pelaez, Fernando, Tatulian, Suren A., Han, Kyu Young, Elliott, Jordan, Baum, Jean, McLean, Pamela J., Dickson, Dennis W., Kim, Yoon-Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564827/
https://www.ncbi.nlm.nih.gov/pubmed/37740734
http://dx.doi.org/10.1007/s00401-023-02632-7

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