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The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer
Various miRNAs have been shown to participate in the tumor progression and development of colorectal cancer (CRC). However, the role of miR-3913-5p in CRC are yet to be clearly defined. In the present study, we determine that miR-3913-5p is downregulated in CRC cell lines and CRC tissues. Exogenous...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564889/ https://www.ncbi.nlm.nih.gov/pubmed/37816820 http://dx.doi.org/10.1038/s42003-023-05405-w |
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author | Dai, Weiyu Hong, Linjie Xiao, Wushuang Zhang, Luyu Sha, Weihong Yu, Zhen Liu, Xuehua Liu, Side Xiao, Yizhi Yang, Ping Peng, Ying Zhang, Jieming Lin, Jianjiao Wu, Xiaosheng Tang, Weimei Lin, Zhizhao Xiang, Li Li, Jiaying Pei, Miaomiao Wang, Jide |
author_facet | Dai, Weiyu Hong, Linjie Xiao, Wushuang Zhang, Luyu Sha, Weihong Yu, Zhen Liu, Xuehua Liu, Side Xiao, Yizhi Yang, Ping Peng, Ying Zhang, Jieming Lin, Jianjiao Wu, Xiaosheng Tang, Weimei Lin, Zhizhao Xiang, Li Li, Jiaying Pei, Miaomiao Wang, Jide |
author_sort | Dai, Weiyu |
collection | PubMed |
description | Various miRNAs have been shown to participate in the tumor progression and development of colorectal cancer (CRC). However, the role of miR-3913-5p in CRC are yet to be clearly defined. In the present study, we determine that miR-3913-5p is downregulated in CRC cell lines and CRC tissues. Exogenous miR-3913-5p expression weakens the CRC cells growth, migration and invasion. Mechanistically, miR-3913-5p directly targets the 3’UTR of CREB5. Overexpression of CREB5 reverses the suppression of CRC cells proliferation, migration and invasion induced by miR-3913-5p. Furthermore, ATF2 negatively regulates the transcription of miR-3913-5p by binding to its promoter. CREB5 can cooperate with ATF2. CREB5 is required for ATF2 in regulating miR-3913-5p. Finally, inverse correlations can be found between the expressions of miR-3913-5p and CREB5 or ATF2 in CRC tissues. Thus, a plausible mechanism of ATF2/miR-3913-5p/CREB5 axis regulating CRC progression is elucidated. Our findings suggest that miR-3913-5p functions as a tumor suppressor in CRC. ATF2/miR-3913-5p/CREB5 axis might be a potential therapeutic target against CRC progression. |
format | Online Article Text |
id | pubmed-10564889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105648892023-10-12 The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer Dai, Weiyu Hong, Linjie Xiao, Wushuang Zhang, Luyu Sha, Weihong Yu, Zhen Liu, Xuehua Liu, Side Xiao, Yizhi Yang, Ping Peng, Ying Zhang, Jieming Lin, Jianjiao Wu, Xiaosheng Tang, Weimei Lin, Zhizhao Xiang, Li Li, Jiaying Pei, Miaomiao Wang, Jide Commun Biol Article Various miRNAs have been shown to participate in the tumor progression and development of colorectal cancer (CRC). However, the role of miR-3913-5p in CRC are yet to be clearly defined. In the present study, we determine that miR-3913-5p is downregulated in CRC cell lines and CRC tissues. Exogenous miR-3913-5p expression weakens the CRC cells growth, migration and invasion. Mechanistically, miR-3913-5p directly targets the 3’UTR of CREB5. Overexpression of CREB5 reverses the suppression of CRC cells proliferation, migration and invasion induced by miR-3913-5p. Furthermore, ATF2 negatively regulates the transcription of miR-3913-5p by binding to its promoter. CREB5 can cooperate with ATF2. CREB5 is required for ATF2 in regulating miR-3913-5p. Finally, inverse correlations can be found between the expressions of miR-3913-5p and CREB5 or ATF2 in CRC tissues. Thus, a plausible mechanism of ATF2/miR-3913-5p/CREB5 axis regulating CRC progression is elucidated. Our findings suggest that miR-3913-5p functions as a tumor suppressor in CRC. ATF2/miR-3913-5p/CREB5 axis might be a potential therapeutic target against CRC progression. Nature Publishing Group UK 2023-10-10 /pmc/articles/PMC10564889/ /pubmed/37816820 http://dx.doi.org/10.1038/s42003-023-05405-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Dai, Weiyu Hong, Linjie Xiao, Wushuang Zhang, Luyu Sha, Weihong Yu, Zhen Liu, Xuehua Liu, Side Xiao, Yizhi Yang, Ping Peng, Ying Zhang, Jieming Lin, Jianjiao Wu, Xiaosheng Tang, Weimei Lin, Zhizhao Xiang, Li Li, Jiaying Pei, Miaomiao Wang, Jide The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer |
title | The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer |
title_full | The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer |
title_fullStr | The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer |
title_full_unstemmed | The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer |
title_short | The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer |
title_sort | atf2/mir-3913-5p/creb5 axis is involved in the cell proliferation and metastasis of colorectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564889/ https://www.ncbi.nlm.nih.gov/pubmed/37816820 http://dx.doi.org/10.1038/s42003-023-05405-w |
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