Creating resistance to avian influenza infection through genome editing of the ANP32 gene family

Chickens genetically resistant to avian influenza could prevent future outbreaks. In chickens, influenza A virus (IAV) relies on host protein ANP32A. Here we use CRISPR/Cas9 to generate homozygous gene edited (GE) chickens containing two ANP32A amino acid substitutions that prevent viral polymerase...

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Detalles Bibliográficos
Autores principales: Idoko-Akoh, Alewo, Goldhill, Daniel H., Sheppard, Carol M., Bialy, Dagmara, Quantrill, Jessica L., Sukhova, Ksenia, Brown, Jonathan C., Richardson, Samuel, Campbell, Ciara, Taylor, Lorna, Sherman, Adrian, Nazki, Salik, Long, Jason S., Skinner, Michael A., Shelton, Holly, Sang, Helen M., Barclay, Wendy S., McGrew, Mike J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564915/
https://www.ncbi.nlm.nih.gov/pubmed/37816720
http://dx.doi.org/10.1038/s41467-023-41476-3

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