CSTF2 mediated mRNA N(6)-methyladenosine modification drives pancreatic ductal adenocarcinoma m(6)A subtypes

N(6)-methyladenosine (m(6)A) modification of gene transcripts plays critical roles in cancer. Here we report transcriptomic m(6)A profiling in 98 tissue samples from 65 individuals with pancreatic ductal adenocarcinoma (PDAC). We identify 17,996 m(6)A peaks with 195 hyper-methylated and 93 hypo-meth...

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Detalles Bibliográficos
Autores principales: Zheng, Yanfen, Li, Xingyang, Deng, Shuang, Zhao, Hongzhe, Ye, Ying, Zhang, Shaoping, Huang, Xudong, Bai, Ruihong, Zhuang, Lisha, Zhou, Quanbo, Li, Mei, Su, Jiachun, Li, Rui, Bao, Xiaoqiong, Zeng, Lingxing, Chen, Rufu, Zheng, Jian, Lin, Dongxin, He, Chuan, Zhang, Jialiang, Zuo, Zhixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564946/
https://www.ncbi.nlm.nih.gov/pubmed/37816727
http://dx.doi.org/10.1038/s41467-023-41861-y

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